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Demberelsuren, Sodbayar

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Товч нэр
Demberelsuren, Sodbayar
Бүтэн нэр
Demberelsuren Sodbayar
Латин нэр
Demberelsuren Sodbayar
Албан тушаал
Судлаач
Харьяалал

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    Item type:Publication,
    Impact of pneumococcal conjugate vaccine 13 introduction on severe lower respiratory tract infections associated with respiratory syncytial virus or influenza virus in hospitalized children in Ulaanbaatar, Mongolia
    (2024-06)
    Do, Lien Anh Ha
    ;
    Tsedenbal, Naranzul
    ;
    Khishigmunkh, Chimidregzen
    ;
    Tserendulam, Bazarkhuu
    ;
    Altanbumba, Lkhagvadorj
    OBJECTIVES: Limited data indicate a beneficial effect of pneumococcal conjugate vaccines (PCVs) on respiratory syncytial virus (RSV) and influenza infections in young children. We evaluated the impact of 13-valent PCV (PCV13) introduction on the incidence of severe lower respiratory tract infections (LRTIs) associated with RSV or influenza in hospitalized children. METHODS: Our study was restricted to children aged <2 years with arterial oxygen saturation <93% and children with radiologically confirmed pneumonia nested in a pneumonia surveillance project in four districts of Ulaanbaatar city, Mongolia. We tested nasopharyngeal swabs collected on admission for RSV and influenza using quantitative reverse transcription-polymerase chain reaction. The impact of PCV13 on the incidence of LRTI outcomes associated with RSV or with influenza for the period April 2015-March 2020 was estimated. Incidence rate ratios comparing pre- and post-vaccine periods were estimated for each outcome for each district using negative binomial models and for all districts combined with a mixed-effects negative binomial model. Adjusted models accounted for seasonality. Sensitivity analyses were conducted to assess the robustness of our findings. RESULTS: Among 5577 tested cases, the adjusted incidence rate ratios showed a trend toward a reduction in RSV-associated outcomes: all LRTIs (0.77, 95% confidence interval [CI] 0.44-1.36), severe LRTIs (0.88, 95% CI 0.48-1.62), very severe LRTIs (0.76, 95% CI 0.42-1.38), and radiologically confirmed pneumonia (0.66, 95% CI 0.32-1.38) but inconsistent trends in outcomes associated with influenza. CONCLUSIONS: No significant reductions were observed in any outcomes associated with RSV and influenza after PCV introduction.
    Scopus© Citations 1