Даваа–Баасан 08:30–20:00 · Бямба 09:00–16:00
library@mnums.edu.mn
/

Yura, Ganbolor

Loading...
Thumbnail Image
Товч нэр
Yura, Ganbolor
Бүтэн нэр
Yura Ganbolor
Латин нэр
Yura Ganbolor
Албан тушаал
Судлаач
Харьяалал
ORCID

Settings

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population
    (Mongolian National University of Medical Sciences, 2025-03-31)
    Ganbayar Batmunkh
    ;
    Munkhtuya Tumurkhuu
    ;
    Myagmarsuren Purevsuren
    ;
    Bayan-Undur Dagvadorj
    ;
    Yerkyebulan Mukhtar
    Objective: Renal cell carcinoma (RCC) is one of the most common malignancies of the kidney, with genetic factors playing a critical role in its development. Among the key genetic factors, TP53 and MDM2 gene polymorphisms have been implicated in cancer susceptibility, but their association with RCC remains unclear in different populations. This study evaluated the association of TP53 and MDM2 gene polymorphisms with RCC risk among Mongolian individuals. Method: In a hospital-based case-control study, 88 RCC cases and 88 matched controls were analyzed for TP53 and MDM2 variants using RFLP-PCR based genotyping. Results: The TP53 CG and CC genotypes and MDM2 TG and GG genotypes were not significantly associated with RCC risk when considered individually. However, individuals carrying the MDM2 GG and TP53 CC genotypes showed elevated RCC risk, although statistical significance was not reached. No strong interaction effects between genotypes and clinical risk factors such as smoking or urinary tract disease were observed. Conclusion: While TP53 and MDM2 polymorphisms showed trends toward association with RCC, larger studies are warranted to clarify their roles in genetic susceptibility within the Mongolian population.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Association of GSTM1, NAT2 Gene Polymorphisms and Susceptibility to Renal cell carcinoma in Mongolia: A Case-Control Study
    (2025-12)
    Batmunkh, Ganbayar
    ;
    Avirmed, Shiirevnyamba
    ;
    Purevsuren, Myagmarsuren
    ;
    Bold, Sodgerel
    ;
    Yura, Ganbolor
    OBJECTIVE: This study aimed to assess the impact of glutathione S-transferase M1 (GSTM1) and N-acetyltransferase 2 (NAT2) polymorphisms on renal cell carcinoma (RCC) risk in Mongolian individuals, both independently and in combination with smoking and urinary tract diseases (UTDs). METHODS: This hospital-based case-control study included 88 histologically confirmed RCC patients and 88 cancer-free controls, matched by age and sex. Genotyping of GSTM1 and NAT2 polymorphisms was performed using PCR-RFLP. RESULTS: There were 34 men and 54 women, with a mean age of 51.9 ± 13.2 years. The results revealed that NAT2 low acetylator genotype significantly increased risk of RCC (cOR=2.077, 95%CI=1.072-4.025, p=0.03). Notably, WT/M3 genotype was significantly associated with RCC risk (aOR=9.1, 95% CI=1.138-72.783; p=0.037). GSTM1-positive genotype significantly increased RCC risk when combined with NAT2 low acetylator genotypes (cOR=3.304, 95% CI=1.311-8.327, p=0.011). Among smokers, individuals with GSTM1-null genotype had an increased risk of RCC (cOR=4.654, 95% CI=1.458-14.86, p=0.009). Additionally, NAT2 low acetylator genotype significantly increased RCC risk in smokers (cOR=6.596, 95% CI=2.26-19.255, p=0.001). Furthermore, both GSTM1 and NAT2 genotypes were associated with significantly increased RCC risk following stratification by a history of urinary tract diseases. CONCLUSION: The findings suggest that the NAT2 WT/M3 polymorphism, along with smoking and UTDs, contributes to RCC susceptibility in Mongolian cases.