Д.Энхмаа
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Товч нэр
Д.Энхмаа
Бүтэн нэр
Дагвадорж Энхмаа
Латин нэр
Dagvadorj Enkhmaa
Эрдмийн цол
Профессор
Боловсролын зэрэг
Доктор (Ph.D)
Харьяалал
ORCID
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Item type:Publication, Bioactive flavonoids from plant extract of Pyrethrum pulchrum and its acute toxicity(Informa UK Limited, 2021-12); Dolgor, ErdenechimegPyrethrum pulchrum Ledeb. has been a phytochemically unexplored Mongolian medicinal folklore plant. In this study, its total flavonoid content was determined and fourteen flavonoids (1-14) were isolated from the aerial parts of P. pulchrum. Their structures were elucidated on the basis of spectroscopic data. The compounds 12-14, methoxyflavones, were tested for antiproliferative and cytotoxic activity against A549, HeLa, K-562, THP-1 and HUVEC cell lines. This is the first report on the effects of 5,7,4'-trihydroxy-3,6,3'-trimethoxyflavone (13) against all tested cell lines and it exhibited potent activity against chronic myeloid leukemia K-562 and acute monocytic leukemia THP-1 cells, each with GI50 value at 2.0 μg/mL. The 5,4'-dihydroxy-3,6,7,3'-tetramethoxyflavone (14) showed the most potent activity against THP-1 (GI50 = 1.1 μg/mL) and the highest cytotoxicity (5.6 μg/mL). In addition, acute toxicity of plant ethanol extract was evaluated and the lethal dose (LD50) was estimated at 1048 mg/kg.