Даваа–Баасан 08:30–20:00 · Бямба 09:00–16:00
library@mnums.edu.mn
/

Jugder, Ganzug

Loading...
Thumbnail Image
Товч нэр
Jugder, Ganzug
Бүтэн нэр
Jugder Ganzug
Латин нэр
Jugder Ganzug
Албан тушаал
Судлаач
Харьяалал

Settings

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Use of Double Test Biomarkers to Predict Fetal Nuchal Translucency Thickness in the Diagnosis of Trisomy 21: A Compromise between Sensitivity and Specificity
    (Mongolian National University of Medical Sciences, 2018-09-25)
    Ganzug Jugder
    ;
    Oyunchimeg Unshigbayar
    ;
    Purevdorj Ichinkhorloo
    ;
    Tsolmon Boldoo
    ;
    Erkhembulgan Purev
    Objectives: The aim of study is to determine the sensitivity and specificity of screening for fetal trisomy 21 in the first trimester of pregnancy using a combination of maternal serum biomarkers and ultrasonography. The objectives of this study were to first duplicate and confirm within the Mongolian population, the results of other similar studies. Our results corroborated closely with those of other studies and further allowed us to draw conclusions and recommendations unique to Mongolia. A second objective was to apply these results to everyday obstetric practices within Mongolia and advance the state of prenatal care for all Mongolian women. Methods: Obstetric History: The obstetric history was recorded, and serum biomarkers were measured in 415 pregnancies.The degree of risk for trisomy 21 and other fetal aneuploidy were calculated using maternal age, the results of maternal serum pregnancy-associated plasma protein-A, free beta human chorionic gonadotropin, and fetal nuchal translucency thickness. Grouping of Test Subjects: Using a cut-off risk estimate of 1 in 300, the women were grouped into positive and negative screening groups. Sensitivity and specificity of the screening method were calculated from the available data. Results: Sensitivity of the screening test for fetal trisomy 21 was 66.6% and for all fetal aneuploidy was 83%. Specificity of the screening test for fetal trisomy 21 was 87.5% and for all fetal aneuploidy was 97.8% and the false positive rate was 2.2%. Our results are consistent with the results obtained in other international studies. Conclusions: Our study is unique in that it is the first such scientific examination of mothers at risk for congenital abnormalities in Mongolia. This study provides empirical evidence that the combination of the double test, maternal age, and fetal nuchal translucency thickness is an effective prenatal screening method for fetal aneuploidy pregnancy outcomes in Mongolia.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Монголд пренатал оношилгооны чиг хандлага
    (2020-01-01)
    Б. Мөнхцэцэг
    ;
    Ө. Оюунчимэг
    ;
    Ж. Ганзүг
    ;
    М. Наранхажид
    ;
    У. Удвал
    Монгол улсад пренатал оношилгоо 2011 оноос эхлэн хөгжиж эхэлсэн бөгөөд жирэмсний эх барихын тусламж үйлчилгээнд ургийн хромосомын эмгэгийг эрт илрүүлж, урьдчилан сэргийлэхийн тулд мэс ажилбарт бус (инвазив бус) аргаас жирэмсний эхний болон хоёр дахь 3 сарын илрүүлэг шинжилгээ (биохимийн маркер тодорхойлох), ЭХО хяналт, мэс ажилбарт (инвазив) аргаас амниоцентез (ураг орчмын шингэн), ихсийн биопсийн (ихсийн цэлмэнгийн эд) шинжилгээг практикт нэвтрүүлсэн байна. 2014 оноос амниоцентез болон цитогенетикийн шинжилгээ ЭХЭМҮТ(Эх Хүүхдийн Эрүүл Мэндийн Үндэсний төв)-д нэвтрүүлж уламжлалт кариотип тодорхойлох шинжилгээ болон FISH (Fluorescent in situ hybridization) техник амжилттай нэвтрүүлсэн байна. Тэгэхээр одоо пренатал оношилгоонд сүүлийн үеийн технологи болох эхийн цусан дахь ургийн чөлөөт ДНХ оношилгооны арга болон преимплантаци мөн ургийн хромосомын микроаррай анализ гэх мэт молекул генетик аргуудыг нэвтрүүлэх л үлдэж байна. Цаашид Монголд пренатал оношилгоо улам боловсронгуй болж өсөх нь дамжиггүй юм.