Д.Мөнхцэцэг
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Д.Мөнхцэцэг
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Даваацэрэн Мөнхцэцэг
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Davaatseren Munkhtsetseg
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Item type:Publication, Mild Ovarian Stimulation for Infertility in Women with Polycystic Ovary Syndrome(Mongolian National University of Medical Sciences, 2022-04-01); ; Objective: The aim of this study was to explore the effect of clomiphene citrate (CC) on the cycle characteristics and outcomes of women with polycystic ovarian syndrome (PCOS) undergoing ovarian stimulation. Methods: This is a cross sectional study, and it was conducted at the tertiary-care medical center. This study included 55 PCOS patients and 54 patients without PCOS undergoing ovarian mild stimulation. In the study group (n = 55), CC and human menopausal gonadotropin (HMG) were administered simultaneously beginning on cycle day 3, while in the control group without PCOS (n = 54) a differing protocol treatment was used. The primary outcome measure was the stimulation day, HMG dose, number of dominant follicles, serum E2, LH, P4 in trigger day and number of oocytes. Secondary outcomes included the number of top-quality embryos, maturation rate, fertilization rate, cleavage rate, incidence of premature LH surge, and OHSS, biochemical and clinical pregnancy rate. Results: The study group received obviously a lower total HMG dose [470.54 ± 304.5 (375–975) vs. 500.00 ± 287.59 IU, but similar HMG duration. While the antral follicle count (AFC) was higher in the study group, the number of oocytes retrieved and top-quality embryos was remarkably less [5 (0 – 30) vs. 13 (0 – 42), 2 (0 –14) vs. 3.5 (0 – 15), p = 0.003, respectively]. The mature oocyte rate was higher in the study group (p = 0.036). No significant differences were detected in fertilization rate and cleavage rate between the 2 groups. CC had a positive influence (higher oocytes retrieved and top-quality embryos) on cycle characteristics, but might be correlated with the impaired IVF outcomes (lower E2, lower implantation rate) in PCOS patients undergoing IVF, when CC + HMG was used simultaneously. Conclusion: In women with PCOS, mild CC stimulation resulted in increased oocytes and viable embryos compared with the control group. The study regimens had a low incidence of OHSS. The results of the CC combined regimen provide new insights into the development of a more patient-friendly protocol for women with PCOS. However, this study needs to be continued on more samples in the future. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Identifying Endometrial Delay Improves Treatment Outcome in Women with Thin Endometrium and Infertility(Mongolian National University of Medical Sciences, 2024-06-30); ; Bum Chae ChoiObjective: To determine the impact of endometrial delay on reproductive outcomes. Method: We enrolled 62 infertility women with thin endometrium pre- and post-study in 2020-2023. Infertile women with an endometrial thickness of <7 mm were included and followed in the study. All participants had endometrial delay determined and adjusted before initial Assisted reproductive technologies (ART). After, infertility treatment was started. ART outcomes were evaluated by endometrial thickness and implantation rate. Endometrial thickness was compared to pre-hormone replacement treatment at 48 and 72 hours post-hormone therapy. Results: The study included 62 women aged 26-45 who were diagnosed with infertility and thin endometrium. Endometrial thickness was sufficiently increased before and after treatment for all participants. Histological analysis diagnosed endometrial delay (not appropriate WOI) in 73.6% of all women. After adjusting the WOI in study participants, there was a statistically significant increase in endometrial thickness post-hormone replacement therapy. The study participants were women who had failed at least one implantation, and the implantation rate after WOI adjustment was 58.5%. Conclusions: In 70% of infertility women, endometrial is delayed. In women with thin endometrium, the precise determination of WOI increases ART treatment outcomes.