Gabiyatu, Baoyinbatu

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Expression of Notch1 in Ameloblastoma and Correlation with CBCT Imaging Subtypes
(Mongolian National University of Medical Sciences, 2023-11-25)
Baoyinbatu Gabiyatu
;
Wenchao Li
;
Wurihan
;
Yuan Tian
;
Lkhagvasuren Baasandorj
Objective: Ameloblastoma (AM) is a prevalent benign odontogenic tumor affecting the jaw bone. Its potential for recurrence and malignant transformation is closely associated with the regulation of signaling pathways. The objective of this study was to examine the expression and clinical significance of Notch1 in AM, along with exploring the correlation between Notch1 expression and AM imaging patterns. Methods: The streptavidin-peroxidase (S-P) immunohistochemical technique was employed to detect the expression of Notch1 protein in the oral mucosa of 70 AM patients and 25 normal controls. Additionally, the preoperative cone-beam computed tomography (CBCT) images of the patients were classified, and the results were analyzed in relation to the expression of Notch1 protein in AM. Results: The positive expression rate of Notch1 in the 70 AM patients was 74.29% (52/70), while the Notch1 expression rate in 26 oral mucosa patients was 19.23% (5/26), indicating a statistically significant difference (P < 0.05). The expression rate of Notch1 was 58.06% in single-room AM and lower in multi-room AM (85.29%) and honeycomb AM (100%) (P < 0.01). However, there was no significant difference in the expression rate of Notch1 between multi-room AM and honeycomb AM (P > 0.05). Conclusion: Notch1 may serve as an important diagnostic indicator in AM, and the apoptosis inhibition ability and cell proliferation ability of single-room AM are lower compared to those of the room and honeycomb types
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Notch1 and CyclinD1 expression and significance in jaw ameloblastoma: an immunohistochemical analysis
(2025-07)
Gabiyatu, Baoyinbatu
;
Li, Wenchao
;
Wu, Rihan
;
Tian, Yuan
;
Li, Senhao
PURPOSE: Ameloblastoma (AM), a frequently encountered odontogenic epithelial neoplasm, demonstrates complex molecular pathogenesis involving dysregulation of cellular signaling networks. This study investigated the clinicopathological significance of Notch1 signaling pathway activation and its downstream effector CyclinD1 in jaw ameloblastoma progression. METHODS: Immunohistochemical profiling was conducted on 66 archived AM specimens and 23 normal oral mucosa (NOM) controls. Protein localization patterns and expression intensities were systematically analyzed using chi-square tests, Fisher's exact test, and Spearman's rank correlation (significance threshold α = 0.05). RESULTS: A notable proportion of jaw AM samples exhibited marked immunoreactivity for Notch1 and CyclinD1 proteins, predominantly localized in the cellular membrane and cytoplasm. Significantly elevated levels of Notch1 and CyclinD1 proteins were evident in AM compared to NOM (P < 0.05). The protein expression levels showed no association with AM subtype (P > 0.05), while a positive correlation between Notch1 and CyclinD1 expression was noted in AM (r = 0.509, P < 0.05). CONCLUSIONS: The coordinated overexpression of Notch1-CyclinD1 axis in ameloblastoma pathogenesis suggests their synergistic involvement in tumor proliferation dynamics. These findings position the Notch signaling pathway as a potential therapeutic target for AM management strategies.
Scopus© Citations 1

Gabiyatu, Baoyinbatu

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