Ganmaa, Davaasambuu

Товч нэр

Ganmaa, Davaasambuu

Бүтэн нэр

Ganmaa Davaasambuu

Латин нэр

Ganmaa Davaasambuu

Албан тушаал

Судлаач

Харьяалал

Анагаахын Шинжлэх Ухааны Үндэсний Их Сургууль

ORCID

0000-0003-3388-8475

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Additional file 2 of Estrogen metabolites in premenopausal women living in China, Mongolia, and the United Kingdom
(Figshare (United Kingdom), 2026-06-10)
Lauren C. Houghton
;
Davaasambuu Ganmaa
;
Isabel Dos Santos Silva
;
Roni Falk
;
Michelle L. Lui
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Additional file 3 of Estrogen metabolites in premenopausal women living in China, Mongolia, and the United Kingdom
(Figshare (United Kingdom), 2026-06-10)
Lauren C. Houghton
;
Davaasambuu Ganmaa
;
Isabel Dos Santos Silva
;
Roni Falk
;
Michelle L. Lui
Supplementary Material 3. Supplemental Table 1. Adjusted least square means for selected metabolites (pg/mL per mg of creatinine).
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Additional file 3 of Estrogen metabolites in premenopausal women living in China, Mongolia, and the United Kingdom
(Figshare (United Kingdom), 2026-06-10)
Lauren C. Houghton
;
Davaasambuu Ganmaa
;
Isabel Dos Santos Silva
;
Roni Falk
;
Michelle L. Lui
Supplementary Material 3. Supplemental Table 1. Adjusted least square means for selected metabolites (pg/mL per mg of creatinine).
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Additional file 1 of Estrogen metabolites in premenopausal women living in China, Mongolia, and the United Kingdom
(Figshare (United Kingdom), 2026-06-10)
Lauren C. Houghton
;
Davaasambuu Ganmaa
;
Isabel Dos Santos Silva
;
Roni Falk
;
Michelle L. Lui
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Additional file 2 of Estrogen metabolites in premenopausal women living in China, Mongolia, and the United Kingdom
(Figshare (United Kingdom), 2026-06-10)
Lauren C. Houghton
;
Davaasambuu Ganmaa
;
Isabel Dos Santos Silva
;
Roni Falk
;
Michelle L. Lui
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Additional file 1 of Estrogen metabolites in premenopausal women living in China, Mongolia, and the United Kingdom
(Figshare (United Kingdom), 2026-06-10)
Lauren C. Houghton
;
Davaasambuu Ganmaa
;
Isabel Dos Santos Silva
;
Roni Falk
;
Michelle L. Lui
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Breast cancer incidence in Mongolia
(Springer Science and Business Media LLC, 2012-07)
Troisi, Rebecca
;
Altantsetseg, Dalkhjav
;
Davaasambuu, Ganmaa
;
Rich-Edwards, Janet
;
Tretli, Steinar
Scopus© Citations 30
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Estrogen metabolites in premenopausal women living in China, Mongolia, and the United Kingdom
(2026-06)
Houghton, Lauren C
;
Ganmaa, Davaasambuu
;
Dos Santos Silva, Isabel
;
Falk, Roni
;
Lui, Michelle L
BACKGROUND: Breast cancer incidence is lower in women living in Asia than women living in North America and Northern Europe. However, large differences exist within Asia, for example, Mongolia's breast cancer rate is even lower than China's. Endogenous estrogens in Asian populations have been hypothesized to explain the disparity because of their strong positive correlations with breast cancer, though few studies have compared estrogen metabolites (EM) within Asia or between Asia and higher breast cancer risk countries. METHODS: We measured urinary concentrations of estradiol and estrone (parent estrogens) and 13 EM (non-parent estrogens) formed by irreversible hydroxylation at the C-2, C-4, or C-16 positions of the steroid ring in premenopausal women living in Ulaanbaatar, Mongolia (n = 282), Shanghai, China (n = 121), and the United Kingdom (n = 125). We performed analysis of variance (ANOVA) using a generalized linear model procedure to assess differences in hormone concentrations between British and Asian (Chinese and Mongolian), and Chinese and Mongolian. Exponentiated least square means were used to calculate percent differences. We compared differences in overall means adjusted for age, body mass index, and parity by country during the follicular, peri-ovulatory, and luteal phases. RESULTS: Total, parent, and non-parent estrogen concentrations were generally higher in British than Asian women, while the non-parent to parent ratio was lower. While parent estrogens appeared higher in Chinese compared with Mongolian women, differences did not reach statistical significance except for peri-ovulatory estrone; total estrogen metabolites in the 2-, 4-, and 16-pathways were higher in Mongolian than Chinese women. The non-parent to parent ratio was highest in Mongolian women followed by Chinese women, with British women having the lowest ratio. CONCLUSION: Total urinary estrogens, both parent and their metabolites, were higher in British compared with Asian women. Our data showing the ratio of non-parent to parent estrogens, possibility reflecting greater estrogen metabolism, in women living in Mongolia, with one of the lowest breast cancer rates globally, than in women living in China, and in Chinese compared with British women, are consistent with their relative breast cancer risks and suggestive of a potentially protective metabolic profile.
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The role of hormones in the differences in the incidence of breast cancer between Mongolia and the United Kingdom
(Public Library of Science (PLoS), 2014)
Troisi, Rebecca
;
Ganmaa, Daavasambuu
;
dos Santos Silva, Isabel
;
Davaalkham, Dambadarjaa
;
Rosenberg, Philip S
BACKGROUND: There are striking differences in breast cancer incidence between Asian and western women. Rates vary substantially within Asia also, with Mongolia's even lower than China's. These profound differences have been speculated to be due in part to diet, mediated by circulating hormone concentrations. METHODS: Sex steroid hormone concentrations were measured in women living in Ulaanbaatar, Mongolia and the United Kingdom (U.K.). Diet was obtained by interview and national survey data. Mean hormone differences were compared by country, and systematic variation by number of days since last menstrual period was modeled and adjusted for age and parity; difference in overall area under the curves was assessed. FINDINGS: The diet in Mongolia was higher in meat and dairy than in the U.K. Mean testosterone concentrations were 18.5% lower (p<0.0001) while estradiol concentrations were 19.1% higher (p = 0.02) in Mongolian than British women, adjusted for age and parity. Progesterone was almost 50% higher in Mongolian women (p = 0.04), particularly during the follicular phase and early luteal surge. Hormone concentrations generally were similar in Mongolian women born in Ulaanbaatar compared with those born in rural areas, although there was a decreasing progesterone trend by degree of westernization (rural Mongolia; urban Mongolia; U.K.). Mean hormone differences were similar when restricted to parous women, and with further adjustment for body mass index, height, and smoking status. INTERPRETATION: These data augment accumulating evidence that circulating estrogens are unlikely to explain reduced breast cancer rates in Asia compared with the west, and suggest casting a wider net with respect to biomarkers. Lower testosterone and higher progesterone in Mongolian women raise the possibility that these hormones may be important to consider. In addition, the almost exclusive dietary reliance of Mongolians on meat and dairy argues against beneficial effects of a low-fat diet on circulating hormones explaining international breast cancer differences.
Scopus© Citations 14
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Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
(MDPI AG, 2016-10)
Houghton, Lauren C
;
Ganmaa, Davaasambuu
;
Rosenberg, Philip S
;
Davaalkham, Dambadarjaa
;
Stanczyk, Frank Z
Breast cancer incidence rates are low but rising in urban Mongolia. We collected reproductive and lifestyle factor information and measured anthropometrics and serum sex steroid concentrations among 314 premenopausal women living in Ulaanbaatar, Mongolia. Mean differences in hormone concentrations by these factors were calculated using age-adjusted quadratic regression splines. Estrone and estradiol in college-educated women were, respectively, 18.2% (p = 0.03) and 23.6% (p = 0.03) lower than in high-school-educated women. Progesterone concentrations appeared 55.8% lower (p = 0.10) in women residing in modern housing compared with women living in traditional housing (gers), although this finding was not statistically significant. Testosterone concentrations were positively associated with adiposity and central fat distribution % difference for highest vs. lowest quarter for body mass index (17.1% (p = 0.001)) and waist-to-height ratio (15.1% (p = 0.005)). Estrogens were higher in the follicular phase of women who breastfed each child for shorter durations. A distinct hormonal profile was associated with an urban lifestyle in premenopausal, Mongol women. In particular, heavier, more-educated women living in urban dwellings had higher testosterone and lower estrogen and progesterone levels. Higher breast cancer incidence in urban compared with rural women suggest that the hormonal profile associated with a more traditional lifestyle may be protective among Mongol women.
Scopus© Citations 12

Ganmaa, Davaasambuu

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