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    Blood Donors with Different Types of Human Constitution Demonstrate Different Level of Cytokines
    (Mongolian National University of Medical Sciences, 2018-06-25) ;
    Soodoi, Chimedtseren
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    ; ;
    Objective: This study was aimed to determine possible relationship between the types of human constitution used in Mongolian traditional medicine and certain types of immune response in healthy blood donors. Materials and methods: Ninety-three blood donors were enrolled in this cross-sectional study. The type of human constitution was determined using the method of Sachs R (1995) and modifi ed by Batchimeg et al. (2003), in which the titer of cytokines (Human IL-2, IL-6, IL-10, IFNγ and TGFβ) in blood plasma and in supernatant of 12- hour PBMC culture were measured by ELISA. Results: Analysis and comparison of different cytokine titers in different constitution groups produced the following fi ndings: Subjects with Badgan ( Tibetan-badken, or phlegm, or bile) type of constitution had a lower activity of Th2 mediated immune response; subjects with Shar ( Tibetan-mkrispa [kris-pa] or mucus) humour domination had a higher activity of Th2 mediated response; and subjects with Khii humour domination may demonstrate higher activity of Th1 mediated response. Conclusion: Human typology types used in Mongolian traditional medicine are likely related to activity or intensity of certain types of adaptive immune responses and authors see an essential need to continue research in this fi eld of study.
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    Functional Abnormalities of the Liver in Diabetic Patients with and without Hepatitis C
    (Mongolian National University of Medical Sciences, 2019-03-31) ; ; ; ;
    Objective: We aimed to compare liver function of diabetes mellitus patients with and without viral hepatitis C using the non-alcoholic fatty liver disease fibrosis score, aspartate transaminase to platelet ratio index, Fibrosis-4 Index, Mac-2-binding protein biomarker and ultrasonic liver stiffness measurements. Methods: The study was conducted based on convenience sampling of 123 patients. Slightly more than half of the study participants were male (53%, n=64). Thirty-three of the diabetics with hepatitis (mean age 52.31±9.8 years) and 90 diabetics without hepatitis (mean age 53.26±8.58) agreed to participate. Anthropometric measurements, non-alcoholic fatty liver disease fibrosis score, aspartate transaminase to platelet ratio index, Fibrosis-4 Index, Mac-2-binding protein biomarker, and ultrasonic transient elastography measurements were compared using independent t-tests for continuous variables and Wilcoxon rank sum tests for ordinal variables. Results: The median values of the Fibrosis-4 Index for those with and without hepatitis C were 1.3 vs. 0.9 (p<.05), Mac-2-binding protein biomarker 2.0 vs. 1.3 (p<.0001), ultrasonic liver stiffness measurements 10.3 vs. 6.9 (p<.0001), aspartate transaminase to platelet ratio 0.6 vs. 0.3 (p<.001), and Non-alcoholic fatty liver disease fibrosis scores were -0.2 vs. -0.9 ( p<.004), respectively Conclusions: Diabetic patients with hepatitis had statistically significantly higher Mac-2-binding protein biomarker, NAFLD Fibrosis Scores than patients without hepatitis. However, other fibrosis test results were similar in diabetic patients with hepatitis and without hepatitis C.