Davaajav, Khishigtogtokh

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Elevated Levels of the Cancer Marker Neuron-Specific Enolase in a Patient With Coexisting Silicosis and Sarcoidosis
(Springer Science and Business Media LLC, 2024-05)
Davaajav, Khishigtogtokh
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Dagva, Dolgormaa
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Dashtseren, Ichinnorov
;
Takahashi, Yoshimitsu
;
Nakayama, Takeo
In a periodical medical checkup, a 39-year-old Mongolian underground miner was diagnosed with silicosis based on chest radiography, computed tomography (CT), and work history. Chest radiography showed diffuse bilateral rounded nodules in both lung fields, with upper lobe dominance and large opacities in the right upper zone. Chest CT presented conglomerated massive changes in the right upper lobe and the coalescence of small nodules in the left upper lung. In the blood test, serum levels of the lung cancer marker neuron-specific enolase (NSE) were elevated (24.58 ng/mL). Carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) levels were within the reference range. Subsequent to the suspicion of a tumour in the right upper lobe, a right upper lobectomy was performed. The histopathological examination of the lung specimen revealed the coalescence of numerous silica nodules, accompanied by indications of associated sarcoidosis. The histological features suggested the presence of two concurrent pathological processes: silicosis and sarcoidosis. This case demonstrated the combination of three clinical conditions diagnosed in one patient, including complicated silicosis associated with sarcoidosis and elevated serum NSE levels. This case report may serve as a foundation for future investigations exploring the potential of NSE as a marker for silicosis.
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Progression of Chest X-ray Findings of Silicosis Among Fluorspar Miners and Prognostic Factors: Retrospective Cohort Study in Mongolia
(Ovid Technologies (Wolters Kluwer Health), 2024-11)
Khishigtogtokh, Davaajav
;
Bayasgalan, Nasanjargal
;
Lkhachinbal, Munkhtsetseg
;
Dashtseren, Ichinnorov
;
Nishikawa, Yoshitaka
OBJECTIVE: This study aimed to delineate the natural progression of silicosis in fluorspar miners after the termination of dust exposure and identify its prognostic factors. METHODS: This retrospective cohort study, conducted from 2000 to 2019, included 67 former miners. Radiological images were evaluated by comparing the initial and most recent radiographs using the International Classification of Radiographs of Pneumoconiosis. Cox multivariate proportional hazard models were used to estimate the hazard ratios using follow-up time to analyze the multivariable study of associated prognostic factors. RESULTS: Among the participants, 50 (75%) exhibited progression over 2 to 16 years (median, 5.8 years). The Cox analysis highlighted older age as a likely precursor to the progression of significant opacities. Additionally, higher International Labour Organization category grades at onset were associated with disease progression. CONCLUSIONS: Nearly three-quarters of the miners diagnosed with silicosis demonstrated radiological progression even after the termination of dust exposure. Advancement in age and the degree of initial radiological opacity were associated with progression.
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Davaajav, Khishigtogtokh

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