Gunchin, Batbaatar
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Товч нэр
Gunchin, Batbaatar
Бүтэн нэр
Gunchin Batbaatar
Латин нэр
Gunchin Batbaatar
Албан тушаал
Судлаач
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Item type:Publication, Impact of Booster Vaccination on Infection and Hospitalization Rates during the Mass Vaccination in Mongolia(Mongolian National University of Medical Sciences, 2025-09-30); ; ; ; Objective: Our study aims to evaluate the effectiveness of booster vaccination in preventing new COVID-19 infections and related hospitalizations among groups that received the primary vaccination series. Methods: Booster vaccination started on August 31, 2021, at recruitment in May 2022. By May 2022, 64% of the Mongolian population had received two primary doses of a COVID-19 vaccine, and 31% had received a booster dose. We followed 1,251 participants (459 males and 792 females, with a mean age of 41.5 ± 14.5 years [18–93], and a median age of 39.0 years) over six months, from the start of booster immunization on September 1, 2021, to February 28, 2022. We compared infection and hospitalization rates among vaccinated groups using logistic regression and calculated vaccine effectiveness (VE) for booster recipients with the formula: VE = 1 – (vaccinated rate/unvaccinated rate) × 100. Results: All participants received two doses of one of four vaccines used in the nationwide campaign. During the study period, we identified 449 new infection cases, accounting for 35.9% of all participants, and 150 subsequent hospitalizations, or 12.0% of the total. Participants who did not receive a booster demonstrated significantly higher infection rates compared to those who did. Booster vaccination provided notably better protection against new infections among frontline workers and reduced hospitalizations in high-risk groups. No significant differences were found in VE when comparing participants based on seroconversion after initial vaccination or the type of booster vaccine used.Conclusion: Therefore, we concluded that COVID-19 booster vaccinations effectively enhanced protection against new SARS-CoV-2 infections among frontline healthcare workers, government employees, and individuals at higher risk for severe disease, thereby reducing their risk of hospitalization. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Histopathological, molecular, and phylogenetic analyses of Echinococcus species isolated from humans in Mongolia, 2010-2024(Elsevier BV, 2026-06); ; ; ; Echinococcosis in humans caused by hydatid cyst of Echinococcus spp., remains a significant public health concern in Mongolia. In this study, we aimed to characterize the epidemiology, histopathological features, and molecular diversity of Echinococcus isolates from human infections. A retrospective analysis of surgically confirmed cases diagnosed between 2010 and 2024 was conducted. A histopathological examination of resected or biopsied cyst material was employed to assess cyst morphology and associated tissue responses. Molecular identification was performed using PCR amplification and sequencing of the mitochondrial cytochrome c oxidase subunit 1 (COX1) gene, followed by Bayesian phylogenetic analysis. A total of 311 human echinococcosis cases from multiple provinces were analyzed. Furthermore, COX1 sequences identified 181 isolates of Echinococcus granulosus sensu stricto (G1), 106 of E. canadensis (G6/7), 19 of E. canadensis (G10), and 5 of E. multilocularis, revealing 11 haplotypes. Geographic clustering of selected genotypes was observed. Bayesian phylogenetic reconstruction demonstrated clustering of Mongolian isolates within established Echinococcus lineages. Time-scaled analyses provided insights into the relative temporal relationships among lineages; however, divergence time estimates were interpreted cautiously owing to reliance on a substitution rate prior and single mitochondrial marker. These findings provide updated epidemiological and molecular data on human echinococcosis in Mongolia. However, given the single-locus design and exclusive use of human-derived samples, interpretations regarding transmission dynamics remain inferential and require confirmation through integrated host-based studies.