Dorjkhuu, Amgalanbaatar
Loading...
Товч нэр
Dorjkhuu, Amgalanbaatar
Бүтэн нэр
Dorjkhuu Amgalanbaatar
Латин нэр
Dorjkhuu Amgalanbaatar
Албан тушаал
Судлаач
ORCID
3 results
Now showing 1 - 3 of 3
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Preliminary Study Results of Native Mongolian Inonotus Obliquus Extracts in Alloxan-Induced Diabetic Rats(Mongolian National University of Medical Sciences, 2020-12-29); ; ; Objectives: We aimed to investigate the morphological changes and clinical chemistry panel of alloxan-induced diabetic rats for the treatment groups of ethanol or aqueous extracts of Mongolian natural Inonotus obliquus. Methods: Wistar albino rats (n = 80) were randomly assigned into four groups: 1. Healthy control group, 2. Untreated diabetic group, 3. Diabetic group treated with Inonotus obliquus (500 mg/kg per day) water extract, 4. Diabetic group with Inonotus obliquus (500 mg/kg per day) ethanol extract. Diabetes was induced by alloxan 150 mg/kg (single intraperitoneal injection) in the diabetic groups. Results: Both water and ethanol extract of Inonotus obliquus reduced the blood glucose level of diabetes at 48 h after treatment. Histologic and morphology examinations showed that water extracts of Inonotus obliquus alleviated the damage to pancreas tissues in alloxan diabetic rats. Conclusions: We postulate that simple ethanol and water extracts of natural Mongolian Inonotus obliquus have an antihyperglycemic effect that enhances islet cell function in alloxan-induced diabetic rats. The extracts of Mongolian natural Inonotus obliquus are easily producible at low cost and should be further explored as a treatment for diabetes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Аллоксаны чихрийн шижинтэй хулганад хусны онгол (inonotus obliquus)-ын усан хандны үзүүлэх нөлөөг судалсан дүн(2023-05-22); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice(Walter de Gruyter GmbH, 2024-12); ; ; ; OBJECTIVES: The Inonotus obliquus is a medicinal mushroom that grows on mature birch trees and is commonly used in traditional medicine for various ailments. The current study aimed to explore the hypoglycemic, hypolipidemic, and pancreatic protective effects of the water extract of Mongolian natural Inonotus obliquus on alloxan-induced diabetic mice. METHODS: Alloxan monohydrate (200 mg/kg) was intraperitoneally single injected into C57BL/6 mice to induce diabetes. Alloxan-induced diabetic mice were orally given the water extract of inonotus obliquus (WEIO) at doses of 500 mg/kg and subcutaneously administered with insulatard 0.6 IU for 4 weeks. Subsequently, the levels of factors related to blood glucose, insulin and lipids were assessed. RESULTS: WEIO significantly restored body weight, reduced fasting blood glucose levels, improved glucose tolerance ability, and increased insulin levels compared to the control diabetic mice. WEIO also enhanced cholesterol transportation in the liver, correlated with increased HDL-C levels and decreased TC, TG and LDL-C levels. Histologic examinations revealed that WEIO alleviated alloxan-induced pancreatic tissue damage. CONCLUSIONS: Natural Mongolian I. Obliquus water extracts have an antihyperglycemic effect and enhance islet cell function in alloxan-induced diabetic mice. It is a good candidate for a hypoglycemic functional food or medicine.Scopus© Citations 2