Batjargal, Azjargal
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Товч нэр
Batjargal, Azjargal
Бүтэн нэр
Batjargal Azjargal
Латин нэр
Batjargal Azjargal
Албан тушаал
Судлаач
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Item type:Publication, Association Between IL-28B Polymorphism and Clinical Laboratory Features in Patients with Chronic Hepatitis D(Mongolian National University of Medical Sciences, 2017-11-25); ; Objectives: We aimed to determine an association between IL-28B rs12989760 single nucleotide polymorphism (SNP) and clinical laboratory parameters in patients with chronic hepatitis D. Methods: A total of 59 patients who were chronically infected with HDV were had their serum tested for the presence of qHBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc, anti-HCV, anti-HDV IgM, anti-HDV IgG, HDV RNA, HBV DNA and AFP. Liver function tests, coagulation tests and CBC were also performed. IL-28B polymorphism was performed using a TaqMan 5' allelic discrimination assay by real time PCR. Results: Of these 59 patients, 40 patients (67.8 %) carried the rs12979860CC homozygote genotype, 11 patients (18.6%) were rs12979860CC homozygote and 8 patients (13.6%) were rs12979860CT heterozygote. Alkaline phosphatase and direct bilirubin values were higher (p<0.05) and total protein levels were lower (p<0.05) in patients who were homozygotes for the T allele as opposed to the carriers of the C allele. AFP levels were significantly higher (p=0.02) in the rs12979860 TT genotype group. Liver enzymes including AST, ALT and GGT were significantly not higher in patients who carry C allele (p>.05). Conclusion: The most frequent genotype was IL-28B rs12979860CC among patients with chronic hepatitis D. The IL-28B rs12979860 polymorphism was associated with some abnormal liver function test parameters and AFP levels. Additional studies are necessary to understand the immune mechanisms of IL-28B polymorphism in HDV infection. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prevalence of major noncommunicable diseases and risk factors by region: Findings from the National Screening(Mongolian National University of Medical Sciences, 2025-12-26); ; ; Objective: Noncommunicable diseases (NCDs) are the leading causes of morbidity and mortality worldwide, accounting for the majority of premature deaths. Mongolia faces a particularly high burden of cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes, contributing to over 80% of total deaths. This study aimed to examine the prevalence of major NCDs and associated risk factors among the adult population of Mongolia by region. Methods: This study utilized large-scale screening data from the mass screening program of adults aged over 18 years. Results: A total of 447,409 adults were included in the analyses. High prevalence of NCD risk factors was observed, including smoking (16.6-19.1%), alcohol use (5.9-11.7%), physical inactivity (76%–80%), and insufficient fruit and vegetable intake (63%–79%). Regional comparison showed that the Northern region had the highest rates of smoking (19.2%), alcohol use (13.4%), and obesity (24.7%) (p<0.001). In contrast, Ulaanbaatar reported notably higher rates of chronic gastritis and peptic ulcer disease (82.2%–18.5%) compared to other rural regions (p<0.001). Conclusion: NCD risk factors are common across all regions of Mongolia, with clear differences between them. Notably, the urban population has higher rates of stomach and esophageal inflammation and ulcers, likely linked to lifestyle factors and obesity.