Vanchin, Byambasuren

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Association between NT- pro BNP and Cardio-metabolic Risk Factors in Mongolians
(2021-07-30)
Bolortuul Byambatsogt
;
Bayasgalan Tumenbayar
;
Ganbat Mijidsuren
;
Ganchimeg Ulziisaikhan
;
Byambasuren Vanchin
Objective of the study was to evaluate the association of NT-pro BNP to cardio-metabolic risk factors, including the metabolic syndrome. Research method: This study was included 194 participant s aged from 35- to 64 years, who were health checkup examinee’s and had no clinical symptoms of heart failure. Cardio-metabolic risk factors were detected by clinical examinations and laboratory test. Metabolic syndrome was defined according to the International Diabetes Federation definition. NT-pro BNP determination was performed on an immunoassay analyzer (FIA8000, Getein Bio Medical Inc). The cut-off point for NT-pro BNP was 125pg/ml. We examined with multivariate linear regression of the relationship between NT-pro BNP and cardio-metabolic risk factors. A logistic regression analysis was also performed to assess the influence of cardio-metabolic risk factors and metabolic syndrome on NT- pro BNP values. Research results: A total of 194 participants included in the study of which, 75 (38.6%) were men and 119 (61.4%) were women. The mean age was 51.3±7.9 75 years. Thirty-two participant s (16.5%) showed elevated NT-pro BNP levels of ≥125 pg/ml. Sixty-one (31.4%) participants had metabolic syndrome. Multivariate linear regression analysis showed that age (β=0.140, P=0.049), systolic blood pressure (β=0.198, P=0.007) and diastolic blood pressure (β=0.174, P=0.018) were positively correlated with NT-pro BNP levels, while body mass index (β=-0.209, P=0.004) was negatively correlated with NT-pro BNP levels. Age (OR=1.07, P=0.011) and hypertension (OR=5.98, P=0.007) were the independent predictors of elevated NT-pro BNP levels. Conclusion: NT-pro BNP levels were significantly increased in participants with hypertension and metabolic syndrome and were lower in obesity.
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H3K27Me3 abundance is associated with a decreased barrier function of endothelial cells by directly silencing VE-cadherin expression.
(2025-07)
Fledderus, Jolien
;
Vanchin, Byambasuren
;
Brouwer, Linda
;
Kuiper, Timara
;
Jongman, Rianne M
Scopus© Citations 7
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Myocardial tissue changes detected by cardiac MRI in a patient with suspected systemic sarcoidosis.
(2023-03)
Vanchin, Byambasuren
;
Ka, Mame Madjiguène
;
Arendt, Christophe T
;
Escher, Felicitas
;
Nagel, Eike
Scopus© Citations 1
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Reciprocal regulation of endothelial-mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease.
(2021-09)
Vanchin, Byambasuren
;
Sol, Marloes
;
Gjaltema, Rutger A F
;
Brinker, Marja
;
Kiers, Bianca
Scopus© Citations 16
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The Endothelium as a Target for Anti-Atherogenic Therapy: A Focus on the Epigenetic Enzymes EZH2 and SIRT1.
(2021-02)
Fledderus, Jolien
;
Vanchin, Byambasuren
;
Rots, Marianne G
;
Krenning, Guido
Scopus© Citations 30
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SARS-CoV-2 seroprevalence in Mongolia: Results from a national population survey
(Elsevier BV, 2021-12)
Chimeddorj, Battogtokh
;
Mandakh, Undram
;
Le, Linh-Vi
;
Bayartsogt, Batzorig
;
Deleg, Zolzaya
BACKGROUND: With the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in early 2020, Mongolia implemented rapid emergency measures and did not report local transmission until November 2020. We conducted a national seroprevalence survey to monitor the burden of SARS-CoV-2 in Mongolia in the months surrounding the first local transmission. METHODS: During October-December 2020, participants were randomly selected using age stratification and invited for interviews and blood samples at local primary health centres. We screened for total SARS-CoV-2 antibodies, followed by two-step quantitative SARS-CoV-2 IgG serology tests for positive samples. Weighted and test-adjusted seroprevalences were estimated. We used chi-square, Fisher's exact and other tests to identify variables associated with seropositivity. FINDINGS: A total of 5000 subjects were enrolled. We detected SARS-CoV-2 IgG antibodies in 72 samples. Crude seroprevalence of SARS-CoV-2 antibodies was 1·44% (95%CI,1·21-1·67). Population weighted and test-adjusted seroprevalences were 1·36% (95%CI,1·11-1·63) and 1·45% (95%CI,1·11-1·63), respectively. Age, sex, geographical, and occupational factors were not associated with seropositivity (p>0·05). Symptoms and signs within past 3 months and seropositivity were not associated at the time of the survey (p>0·05). INTERPRETATION: SARS-CoV-2 seroprevalence in Mongolia was low in the first year of the pandemic potentially due to strong public health measures, including border restrictions, educational facilities closure, earlier adoption of mask-wearing and others. Our findings suggest large-scale community transmission could not have occurred up to November 2020 in Mongolia. Additional serosurveys are needed to monitor the local pandemic dynamic and estimate how far from herd immunity Mongolia will be following-up with vaccination programme in 2021 and 2022. FUNDING: World Health Organisation, WHO UNITY Studies initiative, with funding by the COVID-19 Solidarity Response Fund and the German Federal Ministry of Health (BMG) COVID-19 Research and development. TRANSLATION: Cyrillic and Traditional Mongolian translation of abstract is available on appendix section.
Scopus© Citations 14

Vanchin, Byambasuren

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