Sanjmyatav, Purevjal
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Товч нэр
Sanjmyatav, Purevjal
Бүтэн нэр
Sanjmyatav Purevjal
Латин нэр
Sanjmyatav Purevjal
Албан тушаал
Судлаач
ORCID
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Item type:Publication, Association of Apolipoprotein A-V Gene Polymorphisms and Lipid Metabolism in Mongolian Patients with Metabolic Syndrome(Mongolian National University of Medical Sciences, 2017-06-25); ; Objectives: Our study determined the genetic effect of Apolipoprotein A-V (APOA5) gene polymorphisms on lipid parameters in patients with metabolic syndrome (MetS). Methods: 160 patients with MetS and 144 healthy individuals were selected for the case and control groups, respectively. APOA5 gene polymorphisms (-1131T>C, IVS3+476G>A, c.1177C>T, c.1259T>C) were genotyped using PCR-RFLP. Results: Serum levels of total cholesterol and triglyceride were higher in the MetS group than the control group (p=0.028, p<0.001), while high density lipoprotein levels was lower in the MetS group than the control group (p=0.048). The -1131C allele frequency was higher in the MetS group than the control group (p=0.048). Results of regression analysis showed that APOA5−1131C carriers had increased incidences of MetS (OR=1.87, p=0.010). The frequency of the haplotype C-A-T-C was higher in the MetS group than the control group (p=0.027). In the MetS group, the triglyceride level was significantly higher in the minor allele carriers of -1131T>C, IVS3+476G>A, c.1177C>T. Conclusion: Our results suggest that, among the APOA5 SNPs, the C allele of -1131T>C polymorphism is a risk factor for MetS. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Higher Leptin Level among Mongolians with Metabolic Syndrome as a Predictor of Cardiovascular Risk(Mongolian National University of Medical Sciences, 2017-02-25); ; Objectives: The focus of our research was to determine and identify the cutoff level of leptin in Mongolian adults with metabolic syndrome (MS). Methods: This observed case-controlled study was performed with 259 adults (mean age 40.35±10.75; range 18-71 years old). A questionnaire and anthropological measurements were used for obtaining data. Fasting blood sugar, serum triglyceride, total cholesterol, HDL, adiponectin, leptin, and insulin were measured in fasting blood together with LDL and HOMA-IR calculations. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. Results: Average leptin levels of the group with MS were 10.97±11.32 ng/ml and 23.86±11.32 ng/ml in males and females, respectively. The average leptin level of participants with MS was 17.23±1.59 ng/ml, which was significantly higher than the control group by 10.80±1.58. The MS exposed group had a much higher level of leptin than the control group (p<0.001). Leptin was the predictor of MS in both sexes (AUC-0.839, p<0.0001 for men and AUC-0.737, p<0.0001 for women). Conclusion: Leptin levels in the MS exposed group were higher than in the control group. Leptin may be a useful biomarker of cardiovascular risk in Mongolian adults.