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    Pregnancy Outcome in Women with Gestational Diabetes Mellitus: Age and Pre-pregnancy BMI-Matched Prospective Cohort Study in Ulaanbaatar of Mongolia
    (Mongolian National University of Medical Sciences, 2024-06-30) ; ;
    Chuluunbileg Batbold
    ;
    Objective: This study aimed to assess maternal outcomes in women with Gestational Diabetes Mellitus. Method: A multicenter, age, and pre-pregnancy body mass index-matched prospective cohort study was conducted in five maternity hospitals across Ulaanbaatar, Mongolia, between February and April 2022. All participants (24-28 weeks pregnant) underwent an oral glucose tolerance test (OGTT; 75 g, oral glucose, capillary), and the results were considered as GDM (ADA, 2022). The GDM and non-GDM groups were followed from pregnancy to delivery. Maternal and neonatal delivery outcome data were extracted from the clinical records of five maternity hospitals. Results: The mean age and pre-pregnancy BMI were 35.05±3.8 years and 26.21±3.7 kg/m2, respectively. According to the univariate analysis, women with gestational diabetes had higher rates of pregnancy-induced hypertension, cesarean delivery, and labor induction than the non-GDM group. On the multivariate analysis, the risk of undergoing cesarean delivery and developing pregnancy-induced hypertension were 2.8 (aOR=2.83 CI=1.07-7.47) and 6.9 (aOR=6.91 CI=1.35-35.23) times higher, respectively, in the case group compared to the non-GDM group. Conclusion: Women with GDM had more complications during pregnancy and delivery than those without.
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    Pre-Pregnancy BMI and Gestational Weight Gain Have Independent Associations with Birth Weight: A Prospective Cohort Study in Mongolia
    Background: Neonatal birth weight is a key determinant of short- and long-term health outcomes. Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are important predictors of birth weight; however, their independent associations remain unclear, particularly in settings where national GWG guidelines are lacking. Methods: A prospective cohort study was conducted among 340 pregnant women in Ulaanbaatar, Mongolia in 2022. Data were collected using standardized questionnaires and anthropometric measurements. Pre-pregnancy BMI and GWG were classified according to World Health Organization criteria and the 2009 Institute of Medicine guidelines. Multivariable linear regression models were used to examine independent associations with neonatal birth weight. Results: The mean maternal age, pre-pregnancy BMI, and GWG were 30.3 ± 6.0 years, 23.5 ± 4.4 kg/m2, and 14.3 ± 6.2 kg, respectively. Both BMI and GWG were independently associated with neonatal birth weight (p < 0.001), with no significant interaction observed (p = 0.147). Birth weight increased by 29.7 g (95% CI: 18.6-40.8) per 1 kg/m2 increase in BMI and by 31.7 g (95% CI: 24.0-39.4) per 1 kg increase in GWG. Compared with normal BMI, overweight/obesity was associated with higher birth weight, while excessive GWG increased and inadequate GWG decreased birth weight (all p < 0.05). Conclusions: Pre-pregnancy BMI and GWG were independently associated with neonatal birth weight, with GWG showing a slightly stronger association. These findings highlight the importance of optimizing maternal weight before and during pregnancy. Countries undergoing rapid nutritional transitions may benefit from developing context-specific GWG guidelines, with Mongolia representing a relevant example.