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Oyuntsetseg, Khasag

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Товч нэр
Oyuntsetseg, Khasag
Бүтэн нэр
Oyuntsetseg Khasag
Латин нэр
Oyuntsetseg Khasag
Албан тушаал
Судлаач
Харьяалал
ORCID

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    IDDF2023-ABS-0237 Characteristics of helicobacter pylori from mongolia where burdening high incidence of gastric cancer
    (2023-06-01)
    Boldbaatar Gantuya
    ;
    Batsaikhan Saruuljavkhlan
    ;
    Khasag Oyuntsetseg
    ;
    Yoshio Yamaoka
    ;
    Vo Phuoc Tuan
    Background Globally Mongolia is the top country in the incidence of gastric cancer followed by Japan and Korea which are East Asian countries. Helicobacter pylori (H. pylori) infection possessing East-Asian-type CagA is more associated with gastric carcinogenesis than Western-type CagA. The prevalence of H. pylori is around 70% in Mongolia; however, the previous study reported Mongolians infected with H. pylori possessing Western-type CagA. Therefore, we aimed to characterize Mongolian H. pylori infection based on a whole genome sequencing method. Methods Totally 130 strains are sequenced from Mongolian H. pylori isolates (20 gastric cancer and 110 non-cancer cases) and 401 data from 38 countries H. pylori whole genome data were extracted for the FineStructure analysis. The complete CagA gene and 7 housekeeping genes were extracted for constructing a phylogenetic tree. Results Based on whole genomic FineStructure analysis we found new H. pylori population named as HpMongolia among Mongolian gastric cancer and non-gastric cancer cases which are separately clustered among published global H. pylori populations (IDDF2023-ABS-0237-Figure 1. FineStructure analysis for H.pylori population). Complete CagA gene sequencing data showed that HpMongolia possessed with J-Western type cagA and it was the highest distribution of J-Western cagA positive H. pylori strains identified in Mongolia (67.7%) followed by Canada, North America (10%), and Okinawa, Japan (5.9%) among the published population (IDDF2023-ABS-0237-Figure 2. Global H.pylori phylogenetic tree based on 7-housekeeping genes). The phylogenetic tree constructed based on 7 housekeeping genes result showed the closest H. pylori population with HpMongolia is the HpAmerind which is isolated from native American people (IDDF2023-ABS-0237-Figure 3. H.pylori CagA genotyping map). Conclusions Mongolians provide new H. pylori population is named as HpMongolia which contains most of the cases Japanese-Western type cagA both for cancer and non-cancer cases. Therefore Japanese-Western type cagA might have advantageous for human migration study markers and further clinical implications.
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    Western-Type Helicobacter pylori CagA are the Most Frequent Type in Mongolian Patients
    (MDPI AG, 2019-05)
    Tserentogtokh, Tegshee
    ;
    Gantuya, Boldbaatar
    ;
    Subsomwong, Phawinee
    ;
    Oyuntsetseg, Khasag
    ;
    Bolor, Dashdorj
    Helicobacter pylori infection possessing East-Asian-type CagA is associated with carcinogenesis. Mongolia has the highest mortality rate from gastric cancer. Therefore, we evaluated the CagA status in the Mongolian population. High risk and gastric cancer patients were determined using endoscopy and histological examination. H. pylori strains were isolated from different locations in Mongolia. The CagA subtypes (East-Asian-type or Western-type, based on sequencing of Glu-Pro-Ile-Tyr-Ala (EPIYA) segments) and vacA genotypes (s and m regions) were determined using PCR-based sequencing and PCR, respectively. In total, 368 patients were examined (341 gastritis, 10 peptic ulcer, and 17 gastric cancer). Sixty-two (16.8%) strains were cagA-negative and 306 (83.1%) were cagA-positive (293 Western-type, 12 East-Asian-type, and one hybrid type). All cagA-negative strains were isolated from gastritis patients. In the gastritis group, 78.6% (268/341) had Western-type CagA, 2.9% (10/341) had East-Asian-type, and 18.2% (61/341) were cagA-negative. However, all H. pylori from gastric cancer patients possessed Western-type CagA. Histological analyses showed that East-Asian-type CagA was the most virulent strains, followed by Western-type and cagA-negative strains. This finding agreed with the current consensus. CagA-positive strains were the most virulent type. However, the fact that different CagA types can explain the high incidence of gastric cancer might be inapplicable in Mongolia.
    Scopus© Citations 21