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    Item type:Publication,
    Pancreas-Brain Crosstalk
    (2021) ;
    Mee-Inta, Onanong
    ;
    Zhao, Zi-Wei
    ;
    Hiramoto, Tetsuya
    ;
    The neural regulation of glucose homeostasis in normal and challenged conditions involves the modulation of pancreatic islet-cell function. Compromising the pancreas innervation causes islet autoimmunity in type 1 diabetes and islet cell dysfunction in type 2 diabetes. However, despite the richly innervated nature of the pancreas, islet innervation remains ill-defined. Here, we review the neuroanatomical and humoral basis of the cross-talk between the endocrine pancreas and autonomic and sensory neurons. Identifying the neurocircuitry and neurochemistry of the neuro-insular network would provide clues to neuromodulation-based approaches for the prevention and treatment of diabetes and obesity.
    Scopus© Citations 33