Батсайхан, Саруулжавхлан

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Beyond Low Prevalence: Exploring Antibiotic Resistance and Virulence Profiles in Sri Lankan <i>Helicobacter pylori</i> with Comparative Genomics
(MDPI AG, 2025-01-16)
Fauzia, Kartika Afrida
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Rathnayake, Jeewantha
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Doohan, Dalla
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Lamawansa, Meegahalande Durage
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Alfaray, Ricky Indra
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Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh
(MDPI AG, 2023-01-31)
Fauzia, Kartika Afrida
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Aftab, Hafeza
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Tshibangu-Kabamba, Evariste
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Alfaray, Ricky Indra
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Batsaikhan, Saruuljavkhlan
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Beyond Low Prevalence: Exploring Antibiotic Resistance and Virulence Profiles in Sri Lankan Helicobacter pylori with Comparative Genomics
(MDPI AG, 2025-02-14)
Fauzia, Kartika Afrida
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Rathnayake, Jeewantha
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Doohan, Dalla
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Lamawansa, Meegahalande Durage
;
Alfaray, Ricky Indra
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Fine-scale population structure of Japanese Helicobacter pylori provides new anthropological and epidemiological insights
(2025-06)
Tomonari, Kohei
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Saruuljavkhlan, Batsaikhan
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Alfaray, Ricky Indra
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Fauzia, Kartika Afrida
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Matsunari, Osamu
Helicobacter pylori is considered to contribute to gastric cancer and is also used as a marker to trace human migration due to its co-evolution with humans. To understand the recently proposed tripartite model suggesting three ancestral origins for the Japanese population and address the enigma of the high incidence of gastric cancer in Northeast Hondo (Hondo is mainland Japan), we conducted a fine-scale population structure analysis using a large Japanese H. pylori dataset, including 438 strains from 9 regions based on whole-genome sequences. As a result of fineSTRUCTURE analysis, it was found that H. pylori in Northeast Hondo is genetically distinct from hspEAsia subgroup 7 (sg7), which is widely distributed elsewhere in Hondo. We named this new subgroup hspEAsia-sg8 (Northeast Hondo). Ancestry analysis using ChromoPainter revealed that, while a large proportion of the genomes of hspEAsia-sg8 strains were painted by donors from their own population, the ancestry components of hspEAsia-sg7 showed a high proportion of Chinese and Korean components, suggesting that they were formed through admixture with continental hspEAsia subgroups. These results align with human genome studies, which indicate an original ancestry component in Northeast Hondo and a higher proportion of East Asian components in West Hondo, supporting the tripartite model. This also suggests novel potential for biogeographic ancestry inference in forensic science, as the H. pylori genome can distinguish Hondo populations. Furthermore, fixation index analysis comparing the genome of hspEAsia-sg8 with other Japanese hspEAsia subgroups revealed a high number of nonsynonymous mutations in hp0378 (ccsBA) and hp0377 (dsbC/ccmG). Because these genes are involved in cytochrome c maturation and disulphide bond formation, the detected mutations may affect bacterial survival, growth or pathogenicity. This study supports the tripartite model for the formation of modern Japanese people and suggests that the strain of H. pylori prevalent in the Northeast Hondo region may contribute to the high incidence of gastric cancer there.
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Study of Helicobacter pylori Isolated from a High-Gastric-Cancer-Risk Population: Unveiling the Comprehensive Analysis of Virulence-Associated Genes including Secretion Systems, and Genome-Wide Association Study
(MDPI AG, 2023-09)
Saruuljavkhlan, Batsaikhan
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Alfaray, Ricky Indra
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Oyuntsetseg, Khasag
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Gantuya, Boldbaatar
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Khangai, Ayush
BACKGROUND: The prevalence of gastric cancer in Mongolia, in East Asia, remains the highest in the world. However, most Helicobacter pylori strains in Mongolia have a less virulent Western-type CagA. We aimed to determine how H. pylori genomic variation affected gastric diseases, especially gastric cancer, based on comprehensive genome analysis. METHODS: We identified a set of 274 virulence-associated genes in H. pylori, including virulence factor and outer membrane protein (OMP) genes, the type four secretion system gene cluster, and 13 well-known virulence gene genotypes in 223 H. pylori strains and their associations with gastric cancer and other gastric diseases. We conducted a genome-wide association study on 158 H. pylori strains (15 gastric cancer and 143 non-gastric cancer strains). RESULTS: Out of 274 genes, we found 13 genes were variable depending on disease outcome, especially iron regulating OMP genes. H. pylori strains from Mongolia were divided into two main subgroups: subgroup (Sg1) with high risk and Sg2 with low risk for gastric cancer. The general characteristics of Sg1 strains are that they possess more virulence genotype genes. We found nine non-synonymous single nucleotide polymorphisms in seven genes that are linked with gastric cancer strains. CONCLUSIONS: Highly virulent H. pylori strains may adapt through host-influenced genomic variations, potentially impacting gastric carcinogenesis.

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