Б.Саруулжавхлан

Товч нэр

Б.Саруулжавхлан

Бүтэн нэр

Батсайхан Саруулжавхлан

Латин нэр

Batsaikhan Saruuljavkhlan

Албан тушаал

Гэрээт багш

Харьяалал

Хоол боловсруулах эрхтэн судлалын тэнхим

ORCID

0000-0003-3258-4453

Scopus Author ID

57221996140

Now showing 1 - 5 of 5

Some of the metrics are blocked by your
consent settings
Wild tembelek plant (Lantana camara) as a potential bioactive natural product againts Streptococcus pyogenes in Indonesia
(Universitas Muhammadiyah Surabaya, 2020-01-27)
Ricky Indra Alfaray
;
Rafiqy Sa’adiy Faizun
;
Lionardy Yodianto
;
Batsaikhan Saruuljavkhlan
;
Yudith Annisa Ayu Rezkitha
Abstract Infectious diseases are common problems in most countries. Streptococcus pyogenes is the infectious agent that causes diseases such as pharyngitis, impetigo, toxic shock syndrome, and necrotizing fasciitis. Tembelek (Lantana camara) is a wild plant that can easily be found in every ecosystem in Indonesia whether in nature or settlements and known as a plant that has an antibacterial effect but the knowledge about its potential against Streptococcus pyogenes in this past five years remain scant. The aim of this study was to determine the potentiality of Lantana camara leaves and flowers extract against Streptococcus pyogenes. In this experimental study, in vitro using Post-test Only Control Group Designed, has been done and confirmed by the Indonesian Institute of Sciences. Lantana camara leaves and flowers extracts were obtained by maceration using ethanol. The extracts were diluted into eight concentrations and their antibacterial activity against Streptococcus pyogenes was tested using the Kirby-Bauer disc then proceeded Minimum Inhibitory Concentration (MIC) test and phytochemical assay. The data processed using SPSS software version 22. The results showed that flowers extract had the most significant inhibition zone (11.85 ± 0.119 mm) compared with the leaves extract (9.54 ± 0.07 mm) at the highest tested concentration was 640 mg/ml. The MIC of both extracts was 250 mg/ml. Flavonoids, phenolic, steroids, and saponins were found in both extracts whereas, alkaloid was found only in flowers extract. In conclusion, the Tembelek plant has an antibacterial effect against Streptococcus pyogenes. Future study is needed related to its mechanism of antibacterial effect. Keywords : Antibacterial potential, Lantana camara; Streptococcus pyogenes
Some of the metrics are blocked by your
consent settings
IDDF2022-ABS-0128 A novel pathogen enterococcus hirae induced dysbiosis in the stomach and the genomic instability to promote gastric cancer
(2022-09-01)
Batsaikhan Saruuljavkhlan
;
Boldbaatar Gantuya
;
Junko K. Akada
;
Takashi Matsumoto
;
Ricky Indra Alfaray
Background Previous our microbiome analysis indicates that Enterococcus sp. predominance of microbial composition has been determined in patients with gastric cancer (GC) by 16S rRNA metagenomic analysis. We aimed to determine whether this bacterium could promote the emergence and progression of GC. Methods The effects of E. hirae and Helicobacter pylori (clinical strain Mon-Ke2 as control) were assessed in a gastric epithelial cell line (AGS cells). The cell toxicity of AGS cells is identified by lactate dehydrogenase levels. The DNA double-strand breaks (DSBs) were assessed by gamma-H2AX expressions using immunoblotting; and single-cell gel electrophoresis (SCGE). AGS cells were analyzed for the rapid oxygen species (ROS) expressions response after E. hirae and H. pylori infections. Results E. hirae was successfully isolated from the gastric mucosal specimen of a GC patient for the first time. The whole-genome sequence of E. hirae was confirmed by next-generation sequencing. E. hirae-infected AGS cells showed abnormal morphological changes. Infections of E. hirae and H. pylori significantly induced cell death and expression of gH2AX in AGS cells. Besides, the expression of gH2AX and DSBs was confirmed by SCGE comet formation. Interestingly, co-infection of H. pylori and E. hirae had a synergistic effect on the severity of DSBs. E. hirae could induce intranucleus and mitochondrial ROS in AGS cells same as H. pylori. We investigated whether only live E. hirae, or its released factor(s) can cause DNA damage. Supernatant from AGS cells infected with E. hirae could induce the gH2AX, whereas H. pylori required cell adhesion to induce gH2AX. The complete genome of E. hirae totally contained 2570 genes and 10 known virulence factor genes (e.g., Enterococcus pore-forming toxin). Conclusions E. hirae-related dysbiosis in the stomach might increase the risk for GC, resulting in gained the genomic instability of gastric cells, as well as H. pylori infection. Further research investigating the impacts of this pathogen on the human host using the gastric organoid model is needed since several studies have shown that other species of Enterococcus induce cancer-promoting events resulting in DNA damage in gastric/colonic mucosa, and hepatic cells.
Some of the metrics are blocked by your
consent settings
The effectiveness of classic lecture and workshop as interventions to improve primary health care providers knowledge and skill on the management of pediatric emergencies: a case study
(Universitas Muhammadiyah Surabaya, 2021-01-26)
Ricky Indra Alfaray
;
Rahmat Sayyid Zharfan
;
Yudhistira Pradnyan Kloping
;
Yudith Annisa Ayu Rezkitha
;
Rafiqy Sa’adiy Faizun
Abstract A preliminary study showed that most health workers in primary health care (PHC) claimed that they need a refreshing course because of their lack of updated knowledge and skill. This study enrolled 27 primary healthcare workers recruited from the PHC. The intervention used were classic lectures and workshops. The knowledge was evaluated using a paper-based test and practice, while the skill was evaluated using a practice test. Multiple questions (pre-test and post-test) based on current emergency management for pediatric were used for paper-based evaluation. Semi-structured interviews were conducted to confirm the subject's perspective on the intervention. A paired t-test was used for evaluating the pre- and post-test results, which was confirmed by a triangulation approach. There was a significant difference between the pre- and post-test results (p<0.001), and 8 of 10 subjects can demonstrate the procedure learned correctly after the intervention. A total of 14 interviewed subjects stated great effectiveness of the intervention, with several limitations on applicability in daily clinical practice. Classic lecture and workshop as an intervention in health education effectively increase health workers' knowledge and skill in PHC. This study might help other rural areas PHC apply the same method so the professionalism and quality of health workers in PHC providers can be maintained.Keywords : primary health care, classic lecture; workshop; knowledge; skillCorrespondence : rickyindraalfaray@gmail.com
Some of the metrics are blocked by your
consent settings
The Presence of Other TB Cases in the Family as a Substantial Factor Influencing the Level of Knowledge and Perception of TB patients
(Airlangga University, 2021-06-30)
Yelvi Levani
;
Ricky Indra Alfaray
;
Rahmat Sayyid Zharfan
;
Astri Dewayani
;
Kartika Afrida Fauzia
Introduction: Indonesia is still among the top three contributors to the number of Tuberculosis (TB) patients in the world in 2017. The awareness about TB can be affected by the presence of other TB patients in the family. Perception and good knowledge in TB patients can increase obedient in treatment. This study aims to relate to the presence of other TB patients in the family environment with knowledge of TB patients.Methods: This study used cross-sectional design. Research respondents have taken using the consecutive sampling technique. Respondents were TB patients on category one anti-tuberculosis treatment at Siti Khadijah Sepanjang Hospital and several primary health centers in Sidoarjo region during February-March 2019. This study used a questionnaire which included sociodemographic, level of knowledge, and perception about TB.Results: The number of respondents in this study was 50 people aged 22-67 years old. The level of knowledge of the respondents was mostly good (82%) as well as perceptions regarding TB (78%). Of the 50 patients, 17 patients (34%) claimed some families also suffered from TB. The comparison between group with other TB patient and group without other TB patients in the family showed significantly different result in the level of knowledge (p=0,000) and perception (p=0,000). The presence of other TB cases in family increased level of knowledge and perception regarding TB significantly.Conclusion: The presence of other TB patients in the family environment can increase awareness so that it can increase the interest of TB patients to find information about TB.
Some of the metrics are blocked by your
consent settings
1257 ENTEROCCUS HIRAE ATTENUATES CHEMOKINE AND INDUCES DNA DAMAGE IN GASTRIC EPITHELIAL CELLS
(Elsevier BV, 2023-05-01)
Batsaikhan Saruuljavkhlan
;
Boldbaatar Gantuya
;
Ricky Indra Alfaray
;
Junko K. Akada
;
Takashi Matsumoto

Б.Саруулжавхлан

Filters

Settings

Sort By

Results per page