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Budeebazar, Myagmarjav

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Товч нэр
Budeebazar, Myagmarjav
Бүтэн нэр
Budeebazar Myagmarjav
Латин нэр
Budeebazar Myagmarjav
Албан тушаал
Судлаач
Харьяалал

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    Item type:Publication,
    Peripheral B cells from patients with hepatitis C virus-associated lymphoma exhibit clonal expansion and an anergic-like transcriptional profile
    (2023-01)
    Henning, Amanda N
    ;
    Budeebazar, Myagmarjav
    ;
    Boldbaatar, Delgerbat
    ;
    Yagaanbuyant, Dahgwahdorj
    ;
    Duger, Davaadorj
    Chronic HCV infection remains a global health concern due to its involvement in hepatic and extrahepatic diseases, including B cell non-Hodgkin lymphoma (BNHL). Clinical and epidemiological evidence support a causal role for HCV in BNHL development, although mechanistic insight is lacking. We performed RNA-sequencing on peripheral B cells from patients with HCV alone, BNHL alone, and HCV-associated BNHL to identify unique and shared transcriptional profiles associated with transformation. In patients with HCV-associated BNHL, we observed the enrichment of an anergic-like gene signature and evidence of clonal expansion that was correlated with the expression of epigenetic regulatory genes. Our data support a role for viral-mediated clonal expansion of anergic-like B cells in HCV-associated BNHL development and suggest epigenetic dysregulation as a potential mechanism driving expansion. We propose epigenetic mechanisms may be involved in both HCV-associated lymphoma and regulation of B cell anergy, representing an attractive target for clinical interventions.
    Scopus© Citations 5