М.Баттөр

Товч нэр

М.Баттөр

Бүтэн нэр

Магван Баттөр

Латин нэр

Magvan Battur

Албан тушаал

Багш

Харьяалал

Бичил амь судлал, халдварын сэргийлэлт, хяналтын тэнхим

Scopus Author ID

57349416300

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Хепатит Дельта Вирусийн эпитоп ба нуклеотидийн өвөрмөц байдал
(2023-04-24)
М.Баттөр
;
А. Валкер
;
И.Тимм
;
Ч Баттогтох
ХДВ-ийн 8 хэв шинжээс хамгийн түгээмэл тархсан нь ХДВ-1 юм. ХДВийн нуклеотидын дараалалд гарсан зарим мутацийн үр дүн нь дархлааны урвалаас бултан зайлах нөхцөл бүрдүүлдэг. Хүний HLA аллел нь хамгийн өндөр полиморф шинжтэй ген бөгөөд ХДВ-ийн хэв шинжийн тархалт улс орон бүрт харилцан адилгүй байгаа нь бид өөрийн орны нөхцөлд энэхүү судалгааг хийх үндэслэл боллоо. Монгол хүн амаас ялгасан ХДВ-ийн популяцид HLA-Ⅰ ангийн молекулаар илчлэгдэх боломжит эпитопийг тодорхойлж, эпитопийн бүсд dN ба dS мутацийг илрүүлэхийг зорилоо. Монгол хүн амаас ялгасан ХДВ-ийн 132 шинжлэгдэхүүнд нуклеотидийн дараалал тогтоох шинжилгээний дүнгээр ХДВ-1-р хэв шинжийн 4 дэд хэв шинж илэрсэн. Эдгээр дэд хэв шинжийн 2 нь 1с ба 1d бүлэгт хамаарагдаж байсан бол бусад 2 бүлэг нь шинэ дэд бүлэг байв. ХДВ-ийн нуклеотидийн 30 байршилд dN, 60 байрлал дээр dS мутацийг илэрлээ. HLA-Ⅰ ангийн 85 молекул тогтоож, ХДВ-ийн эпитопийг тодорхойлоход HLA-Ⅰ ангийн 35 молекул ХДВ-ийн эпитопийг илчлэх боломжтой байв. HLA-B*27:05 (49 эпитоп), HLA-B*41:01 (26 эпитоп), HLA-C*03:03 (22 эпитоп), HLA-B*55:02 (19 эпитоп), HLA-A*68:01 (15 эпитоп) тус бүр илчлэх боломжтойг тогтоолоо. Харин HLA-A*01:01, HLA-A*11:01, HLA-A*:02:07 молекулууд тус бүр 1-2 эпитоп илчлэх боломжтой байв. ХДВ-ийн эпитопийг илчлэх хамгийн өндөр боломжит HLA-B*27:05 молекул байна. Эпитопийн бүсд үүссэн dN мутаци нь дархлааны хариу урвалаас зайлсхийх нөхцлийг бүрдүүлж байна.
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ХДХВ-ийн халдваргүй хүмүүсд CCR5 генийн полиморфизмыг илрүүлсэн дүн
(2021-09-01)
М.Баттөр
;
Андереас Валкер
;
Б.Даваадорж
;
Э.Гэрэлмаа
;
Г.Ануужин
. Хүний Дархлал Хомсдолын Вирусийн (ХДХВ) gp41 уураг CCR5 ко-рецептортой холбогдсноор вирус эсийн дотогш нэвтрэн ордог. Хүн амын дунд CCR5 генийн мутацийн олон хувилбар тохиолддог бөгөөд эдгээрээс CCR5 ∆32 мутацтай бодгаль ХДХВ халдварт тэсвэртэй байдаг. Дэлхийн хүн амын дунд CCR5 ∆32 мутац Европ тивийн хүн амд их тохиолддог бол Ази тивийн хүн амд хамгийн бага хувьтай байдаг. Энэ судалгаанд насанд хүрсэн 90 хүн хамруулсан бөгөөд генийн мутацийг илрүүлэх шинжилгээг ХБНГУ-ын Хенрих Хайнийн Их Сургуулийн Вирус судлалын институтид хийсэн. Cудалгааны ажлын үр дүнгээс харахад CCR5∆32 мутаци 4.4% (4/90), R223Q мутаци 32.2% (29/90) байв. Монгол хүмүүсийн дунд CCR5∆32 мутацийн тархалт ази тивийн хүн амын дундах тархалттай ойролцоо байна. Харин R223Q мутац харьцангуй өндөр байна.
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Sequence diversity of hepatitis D virus in Mongolia
(2023)
Magvan, Battur
;
Kloeble, Anne Alina
;
Ptok, Johannes
;
Hoffmann, Daniel
;
Habermann, Daniel
INTRODUCTION: The Hepatitis Delta Virus (HDV) is a defective, single-stranded RNA virusoid encoding for a single protein, the Hepatitis Delta Antigen (HDAg), which requires the hepatitis B virus (HBV) envelope protein (HBsAg) for its transmission. Currently, hepatitis D is the most aggressive form of viral hepatitis and treatment options are limited. Worldwide 12 million people are chronically infected with HDV being at high risk for progression to cirrhosis and development of liver cancer. OBJECTIVES: Although it is well established that Mongolia is the country with the highest prevalence of HDV infections, the information on the molecular epidemiology and factors contributing to HDV sequence diversity are largely unclear. The aim of the study was to characterize the sequence diversity of HDV in rural areas from Mongolia and to determine the extent of HLA class I-associated selection pressure. PATIENTS AND METHODS: From the HepMongolia cohort from rural areas in Mongolia, 451 HBsAg-positive individuals were selected and anti-HDV, HDV-RNA and the sequence of the large HDAg was determined. For all individuals the HLA class I locus was genotyped. Residues under selection pressure in the presence of individual HLA class I types were identified with the recently published analysis tool HAMdetector. RESULTS: Of 431 HBsAg positive patients, 281 were anti-HDV positive (65%), and HDV-RNA could be detected in 207 of 281 (74%) of patients. The complete large HDAg was successfully sequenced from 131 samples. Phylogenetic analysis revealed that all Mongolian HDV isolates belong to genotype 1, however, they separate into several different clusters without clear regional association. In turn, from phylogeny there is strong evidence for recent local transmission events. Importantly, we found multiple residues with strong support for HLA class I-associated selection pressure consistent with a functional CD8+ T cell response directed against HDV. CONCLUSION: HDV isolates from Mongolia are highly diverse. The molecular epidemiology suggests circulation of multiple subtypes and provides evidence for ongoing recent transmissions.
Scopus© Citations 10
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SARS-CoV-2 seroepidemiology in Mongolia, 2020-2021: a longitudinal national study
(Elsevier BV, 2023-04)
Chimeddorj, Battogtokh
;
Bailie, Christopher R
;
Mandakh, Undram
;
Price, David J
;
Bayartsogt, Batzorig
BACKGROUND: The COVID-19 pandemic has global impacts but is relatively understudied in developing countries. Mongolia, a lower-middle-income country, instituted strict control measures in early 2020 and avoided widespread transmission until vaccines became available in February, 2021. Mongolia achieved its 60% vaccination coverage goal by July 2021. We investigated the distribution and determinants of SARS-CoV-2 seroprevalence in Mongolia over 2020 and 2021. METHODS: We performed a longitudinal seroepidemiologic study aligned with WHO's Unity Studies protocols. We collected data from a panel of 5000 individuals in four rounds between October 2020 and December 2021. We selected participants through local health centres across Mongolia by age-stratified multi-stage cluster sampling. We tested serum for the presence of total antibodies against SARS-CoV-2 receptor-binding domain, and levels of anti-SARS-CoV-2 spike IgG and neutralising antibodies. We linked participant data with national mortality, COVID-19 case, and vaccination registries. We estimated population seroprevalence and vaccine uptake, as well as unvaccinated population prior-infection prevalence. FINDINGS: At the final round in late 2021, 82% (n = 4088) of participants completed follow-up. Estimated seroprevalence increased from 1.5% (95% CI: 1.2-2.0), to 82.3% (95% CI: 79.5-84.8) between late-2020 and late-2021. At the final round an estimated 62.4% (95% CI: 60.2-64.5) of the population were vaccinated, and of the unvaccinated population 64.5% (95% CI: 59.7-69.0) had been infected. Cumulative case ascertainment in the unvaccinated was 22.8% (95% CI: 19.1%-26.9%) and the overall infection-fatality ratio was 0.100% (95% CI: 0.088-0.124). Health workers had higher odds for being COVID-19 confirmed cases at all rounds. Males (1.72 (95% CI: 1.33-2.22)) and adults aged 20 and above (12.70 (95% CI: 8.14-20.26)) had higher odds for seroconverting by mid-2021. Among the seropositive, 87.1% (95% CI: 82.3%-90.8%) had SARS-CoV-2 neutralising antibodies by late 2021. INTERPRETATION: Our study enabled tracking of SARS-CoV-2 serological markers in the Mongolian population over one year. We found low SARS-CoV-2 seroprevalence in 2020 and early 2021, with seropositivity increasing over a 3-month interval in 2021 due to vaccine roll out and rapid infection of most of the unvaccinated population. Despite high seroprevalence in Mongolia amongst both vaccinated and unvaccinated individuals by end-2021, the SARS-CoV-2 Omicron immune escape variant caused a substantial epidemic. FUNDING: World Health Organization, WHO UNITY Studies initiative, with funding by the COVID-19 Solidarity Response Fund and the German Federal Ministry of Health (BMG) COVID-19 Research and development. The Ministry of Health, Mongolia partially funded this study.
Scopus© Citations 6
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SARS-CoV-2 seroprevalence in Mongolia: Results from a national population survey
(Elsevier BV, 2021-12)
Chimeddorj, Battogtokh
;
Mandakh, Undram
;
Le, Linh-Vi
;
Bayartsogt, Batzorig
;
Deleg, Zolzaya
BACKGROUND: With the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in early 2020, Mongolia implemented rapid emergency measures and did not report local transmission until November 2020. We conducted a national seroprevalence survey to monitor the burden of SARS-CoV-2 in Mongolia in the months surrounding the first local transmission. METHODS: During October-December 2020, participants were randomly selected using age stratification and invited for interviews and blood samples at local primary health centres. We screened for total SARS-CoV-2 antibodies, followed by two-step quantitative SARS-CoV-2 IgG serology tests for positive samples. Weighted and test-adjusted seroprevalences were estimated. We used chi-square, Fisher's exact and other tests to identify variables associated with seropositivity. FINDINGS: A total of 5000 subjects were enrolled. We detected SARS-CoV-2 IgG antibodies in 72 samples. Crude seroprevalence of SARS-CoV-2 antibodies was 1·44% (95%CI,1·21-1·67). Population weighted and test-adjusted seroprevalences were 1·36% (95%CI,1·11-1·63) and 1·45% (95%CI,1·11-1·63), respectively. Age, sex, geographical, and occupational factors were not associated with seropositivity (p>0·05). Symptoms and signs within past 3 months and seropositivity were not associated at the time of the survey (p>0·05). INTERPRETATION: SARS-CoV-2 seroprevalence in Mongolia was low in the first year of the pandemic potentially due to strong public health measures, including border restrictions, educational facilities closure, earlier adoption of mask-wearing and others. Our findings suggest large-scale community transmission could not have occurred up to November 2020 in Mongolia. Additional serosurveys are needed to monitor the local pandemic dynamic and estimate how far from herd immunity Mongolia will be following-up with vaccination programme in 2021 and 2022. FUNDING: World Health Organisation, WHO UNITY Studies initiative, with funding by the COVID-19 Solidarity Response Fund and the German Federal Ministry of Health (BMG) COVID-19 Research and development. TRANSLATION: Cyrillic and Traditional Mongolian translation of abstract is available on appendix section.
Scopus© Citations 14
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Histopathological Features of Hepatocellular Carcinoma in Patients with Hepatitis B and D Virus Infection: A Single-Institution Study in Mongolia
(MDPI AG, 2025-01)
Jargalsaikhan, Orgil
;
Shao, Wenhua
;
Ichimura-Shimizu, Mayuko
;
Ishimaru, Soichiro
;
Koma, Takaaki
Background: Viral hepatitis, particularly hepatitis B (HBV) and hepatitis C (HCV), is highly prevalent in Mongolia. Moreover, Mongolia has the highest prevalence of hepatitis delta virus (HDV) globally, with over 60% of HBV-infected individuals also co-infected with HDV. Since HBV/HDV infections accelerate liver disease progression more compared to HBV infection alone, urgent national health measures are required. Method: This study presents a clinicopathological analysis of 49 hepatocellular carcinoma cases surgically resected at the Mongolia-Japan Hospital of the Mongolian National University of Medical Sciences. Results: HBV infection was found in 27 (55.1%) cases of all HCC cases. Immunohistochemical staining of the liver revealed that 14 (28.6%) cases were HDV antigen-positive in the HCC cases. HDV-positive cases exhibited significantly higher inflammatory activity compared to HDV-negative cases, with lymphocytic infiltrates predominantly composed of CD4-positive cells. Furthermore, HDV-positive cells were spatially distinct from HBs antigen-positive cells, suggesting that HDV-infected cells may interfere with HBV replication. No significant differences in fibrosis or in tumor characteristics were observed between the HDV-positive and negative cases. Early diagnosis of HBV/HDV infections is essential for appropriate treatment and to prevent further domestic transmission of the virus. However, routine testing for HDV infection is rarely conducted in Mongolia. Since HDV-positive cells are morphologically indistinguishable from surrounding HDV-negative cells, routine histopathological analysis may not be sufficient enough to detect HDV infection. Conclusions: Based on this clinicopathological study, CD4 and CD8 immunostaining can be considered an adjunctive diagnostic tool in cases with significant lymphocytic infiltration and hepatocellular damage. Additionally, HDV screening using blood and tissue samples may be recommended to ensure accurate diagnosis.
Scopus© Citations 1

М.Баттөр

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