Battulga, Tungalag
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Товч нэр
Battulga, Tungalag
Бүтэн нэр
Battulga Tungalag
Латин нэр
Battulga Tungalag
Албан тушаал
Судлаач
ORCID
Scopus Author ID
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Item type:Publication, Network pharmacology and experimental evaluation of Sanwei Tanxiang Tangsan in doxorubicin-induced heart failure(2026-06); ; GuiZhiBACKGROUND: Heart failure (HF) is a complex syndrome characterized by inflammation, oxidative stress, and cardiomyocyte apoptosis, for which effective and well-tolerated therapies remain limited. This study sought to explore the potential mechanisms by which Mongolian medicine Sanwei Tanxiang Tangsan (STX) may be associated with AKT1/p53-related signaling in the mitigation of HF, employing network pharmacology, molecular docking, and animal experimentation. MATERIALS AND METHODS: Active constituents and corresponding targets of Mongolian medicine STX were systematically screened, followed by the construction of drug-disease interaction networks to identify pivotal proteins and pathways. A doxorubicin-induced HF rat model was established, and after four weeks of intragastric administration of Mongolian medicine STX and sacubitril/valsartan (angiotensin receptor-neprilysin inhibitor, positive control), cardiac functional parameters and expression levels of AKT protein 1 (AKT1), interleukin-6 (IL-6), and p53 were assessed. RESULT: Nineteen active components were identified in Mongolian medicine STX, interacting with 153 HF-associated targets, among which AKT1, IL-6, and TP53 served as the core genes. Molecular docking analysis revealed that quercetin and luteolin possessed moderate predicted binding affinities and stable interactions with the corresponding targets. Animal experiments indicated that Mongolian medicine STX significantly reduced N-terminal pro-brain natriuretic peptide levels and altered myocardial AKT1, IL-6, and p53 protein abundance. However, echocardiographic parameters showed no statistically significant improvement compared with the Model group. CONCLUSION: Mongolian medicine STX may exert cardioprotective effects in HF, as reflected by improvements in biochemical and histopathological indicators, and these effects may be associated with AKT1/p53-related signaling pathways. However, direct pathway activation and causal mechanisms were not confirmed in the present study and require further investigation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Natural products reverse cancer multidrug resistance(Frontiers Media SA, 2024); Abdelmohsen, Usama RamadanCancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor MDR. Discovering novel potential modulators to reduce tumor MDR by Natural Product-Derived Compounds has become a popular research area across the globe. Numerous studies mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their MDR modulatory activity. Natural products reverse MDR by regulating signaling pathways or the relevant expressed protein or gene. Here we perform a deep review of the previous achievements, recent advances in the development of natural products as a treatment for MDR. This review aims to provide some insights for the study of multidrug resistance of natural products.Scopus© Citations 53