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    Association between hand-grip strength and risk of stroke among Mongolian adults: Results from a population-based study
    (2021-08-30) ; ;
    Anujin Tuvshinjargal
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    Mongolia ranks third in the world in stroke-related deaths. Loss of skeletal muscle mass and function, known as sarcopenia, is associated with a higher risk of various metabolic disorders such as stroke. Thus, screening of sarcopenia is important. Hand-grip strength (HGS) can be used to predict sarcopenia in the short term. In this cross-sectional study, we used data (n=1180, mean age of 39.2 ± 15.2 and 33.2% males) from the Mon-Timeline cohort study, a multidisciplinary, prospective, population-based cohort study in Mongolia. A digital grip strength dynamometer (TKK 5401 GRIP D; Takei, Japan) was used to measure HGS. We performed binary logistic regression analysis between HGS and stroke risk. Suspected sarcopenia was defined when HGS is less than the 25th percentile of HGS. In this study, 3.3% of all participants had a stroke. The incidence of stroke was significantly higher (5.2% and 1.9%) in people with suspected sarcopenia. According to body composition, the incidence of stroke was more frequent in sarcopenic obese people: 1.3%, 2.4%, 2.8% and 6.2% in normal (non-obese and non-sarcopenic), sarcopenic (non-obese), obese (non-sarcopenic) and sarcopenic obese groups, respectively. In regression analysis, the OR (95% CI) was 2.84 (1.44; 5.59) for sarcopenic compared with non-sarcopenic. The adjustments for age, gender, education, body mass index, waist circumference and hypertensive status attenuated the associations, but lower HGS remained significantly associated with a higher risk of stroke. In conclusion, lower HGS was significantly associated with a higher risk of stroke independent of adiposity and hypertensive status in Mongolian adults.
    Scopus© Citations 5
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    High prevalence of thyroid nodules and their association with cardiometabolic risk in Mongolia
    INTRODUCTION: Mongolia faces rising rates of obesity, diabetes, and cardiovascular disease, yet little is known about their relationship with thyroid nodules. This study aimed to assess the prevalence of thyroid nodules and their association with cardiometabolic outcomes in the Mongolian population. METHODS: A nationwide retrospective analysis was conducted among 36,395 adults who underwent thyroid ultrasound during routine health checkups. Demographic, anthropometric, and metabolic parameters were recorded, including body mass index (BMI), central obesity, blood pressure, diabetes, and cardiovascular risk based on WHO criteria. RESULTS: Thyroid nodules were identified in 40.3% (n = 14,651) of participants. Age-adjusted prevalence was 32.1% overall, 19.8% in men, and 39.2% in women, with higher rates in Ulaanbaatar (43.9%) than in rural areas (35.4%). Participants with nodules had higher BMI, central obesity, diabetes, and cardiovascular risk compared to those without nodules. Prevalence was greatest in the very high CVD risk category (60.0% in women, 33.1% in men). Multivariate models confirmed independent associations between thyroid nodules and age, female sex, obesity, and cardiovascular risk. CONCLUSIONS: Thyroid nodules are highly prevalent in Mongolia and cluster with adverse cardiometabolic outcomes. Nodules may serve as a clinical marker of elevated cardiovascular risk. Future longitudinal studies should explore potential bidirectional pathways between obesity, thyroid nodules, and cardiometabolic disease.