Loading...
Transmission of SARS-CoV-2 in standardised first few X cases and household transmission investigations: A systematic review and meta-analysis
Зохиогч
Lewis, Hannah C
Marcato, Adrian J
Meagher, Niamh
Valenciano, Marta
Villanueva-Cabezas, Juan-Pablo
Spirkoska, Violeta
Fielding, James E
Karahalios, Amalia
Subissi, Lorenzo
Nardone, Anthony
Cheng, Brianna
Rajatonirina, Soatiana
Okeibunor, Joseph
Aly, Eman A
Barakat, Amal
Jorgensen, Pernille
Azim, Tasnim
Wijesinghe, Pushpa R
Le, Linh-Vi
Rodriguez, Angel
Vicari, Andrea
Van Kerkhove, Maria D
McVernon, Jodie
Pebody, Richard
Price, David J
Bergeri, Isabel
Unity Studies Collaborator Group
Al Ariqi, Lubna
Alemu, Mikias A
Alvi, Yasir
Bukusi, Elizabeth A
Chung, Pui Shan
Das, Ayan K
Dub, Timothée
Dulacha, Diba
Ebrahim, Faiqa
González-Duarte, Maritza A
Guruge, Dinuka
Heraud, Jean-Michel
Heredia-Melo, Damaris C
Herman-Roloff, Amy
Herring, Belinda L
Inbanathan, Francis Y
Islam, Farzana
Jeewandara, Kamal Chandima
Kant, Shashi
Khan, Wasiq
Lako, Richard
Leite, Juliana
Malavige, Gathsaurie Neelika
Mandakh, Undram
Mariam, Warisha
Mend, Tsogt
Mize, Valerie A
Musa, Sanjin
Nohynek, Hanna
Olu, Olushayo O
Osorio-Merchán, May B
Pereyaslov, Dmitriy
Randremanana, Rindra Vatosoa
de Dieu Randria, Mamy Jean
Ransom, James
Saxena, Sonal
Sharma, Pragya
Sreedevi, Aswathy
Satheesh, Mini
Subhashini, K J
Tippet-Barr, Beth A
Usha, Anuja
Wamala, Joseph F
Watare, Shambel H
Yadav, Kapil
Он
2022 оны есдүгээр сар
Төрөл
journal article
Хэвлэгч
Wiley
Journal
Influenza and other respiratory viruses
Volume
16
Issue
5
Start Page
803
End Page
819
ISSN
1750-2659
Хураангуй
We aimed to estimate the household secondary infection attack rate (hSAR) of SARS-CoV-2 in investigations aligned with the WHO Unity Studies Household Transmission Investigations (HHTI) protocol. We conducted a systematic review and meta-analysis according to PRISMA 2020 guidelines. We searched Medline, Embase, Web of Science, Scopus and medRxiv/bioRxiv for "Unity-aligned" First Few X cases (FFX) and HHTIs published 1 December 2019 to 26 July 2021. Standardised early results were shared by WHO Unity Studies collaborators (to 1 October 2021). We used a bespoke tool to assess investigation methodological quality. Values for hSAR and 95% confidence intervals (CIs) were extracted or calculated from crude data. Heterogeneity was assessed by visually inspecting overlap of CIs on forest plots and quantified in meta-analyses. Of 9988 records retrieved, 80 articles (64 from databases; 16 provided by Unity Studies collaborators) were retained in the systematic review; 62 were included in the primary meta-analysis. hSAR point estimates ranged from 2% to 90% (95% prediction interval: 3%-71%; I 2 = 99.7%); I 2 values remained >99% in subgroup analyses, indicating high, unexplained heterogeneity and leading to a decision not to report pooled hSAR estimates. FFX and HHTI remain critical epidemiological tools for early and ongoing characterisation of novel infectious pathogens. The large, unexplained variance in hSAR estimates emphasises the need to further support standardisation in planning, conduct and analysis, and for clear and comprehensive reporting of FFX and HHTIs in time and place, to guide evidence-based pandemic preparedness and response efforts for SARS-CoV-2, influenza and future novel respiratory viruses.