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Impact of Oocyte Morphologic Abnormalities on Embryo Development
Зохиогч
Purevjargal Naidansuren
Bum Chae Choi
Park Hyo Young
Он
2024 оны зургаадугаар сарын 30
Төрөл
journal article
Хэвлэгч
Mongolian National University of Medical Sciences
Journal
Central Asian Journal of Medical Sciences
Volume
10
Issue
2
Start Page
76
End Page
84
ISSN
2413-8681
2414-9772
Хураангуй
Objectives: This study aimed to investigate the relationship between oocyte morphologic features and embryo development following an Intracytoplasmic Sperm Injection (ICSI) procedure. Methods: In this retrospective study, 485 mature oocytes were obtained from 70 patients undergoing ICSI cycles. Controlled ovarian stimulation was performed using a standard antagonist protocol. Morpho kinetic variables were analyzed using Time-Lapse Monitoring (TLM). The primary outcome measures were fertilization and reasonable embryo rate. Results: The patients’ age ranged from 22 to 45 years (34.9±4.9 on average). From all retrieved MII oocytes, 285 (59.0%) showed at least one morphologic aberration. The organelle cluster and ovoid shape were related to a lower fertilization rate (OR: 0.35 p-value 0,045 and OR:0.137; p-value 0,048, respectively). Time to 5 cells (t5) and time to 7 cells (t7) were different between normal and abnormal morphologic oocytes (P-value 0.016 and 0.017, respectively). Average Oocyte Quality Index (AOQI) negatively correlated with the number of good embryos. Conclusions: In our study, the fertilization potential of organelle clusters and ovoid-shaped oocytes was lower. The t5 and t7 were significantly longer in the abnormal oocyte group.