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Adiponection/Leptin Ratio and Insulin Resistance among Mongolians with Metabolic Syndrome
Зохиогч
Он
2018 оны гуравдугаар сарын 25
Төрөл
journal article
Хэвлэгч
Mongolian National University of Medical Sciences
Journal
Central Asian Journal of Medical Sciences
Volume
4
Issue
1
Start Page
69
End Page
75
ISSN
2413-8681
2414-9772
Хураангуй
Objectives: In this study, we aimed to determine the relationship between adiponectin/leptin (A/L) ratio and insulin resistance among Mongolian subjects with metabolic syndrome (MetS). Methods: The study was comprised of 364 adults. Fasting blood glucose, total cholesterol, triglyceride, and high density lipoprotein cholesterol were measured. Serum adiponectin and leptin were measured using enzyme-linked-immunoassay. Low density lipoprotein cholesterol and homeostatic model assessment-insulin resistance (HOMA-IR) were calculated. Results: Serum adiponectin was inversely correlated with diastolic blood pressure, body mass index, waist circumference, serum triglyceride, and fasting insulin level (r=-0.118, r=-0.190, r=-0.244, r=-0.231, and r=-0.165, respectively) (p<0.001). Serum leptin was significantly correlated with all risk factors of metabolic syndrome, except for lipid parameters (p<0.001). In the multiple regression analysis, HOMA-IR was significantly associated with adiponectin and A/L ratio among males with MetS, after adjustment for other factors. Conclusion: The A/L ratio was a significant predictor for insulin resistance among male adults with MetS.