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Phytochemical Characterization and Nephroprotective Effects of Taraxacum officinale F.H.Wigg Extract in a Gentamicin Induced Acute Nephrotoxicity Rat Model
Зохиогч
Dejidmaa Buyantogtokh
Enkhzaya Lkhagvadorj
Anu Altangerel
Nyamdolgor Uranbileg
Yaroslav V. Faletrov
Gundsambuu Tserenkhand
Chimedragchaa Chimedtseren
Он
2026 оны зургаадугаар сарын 25
Төрөл
journal article
Хэвлэгч
Oriental Scientific Publishing Company
Journal
Biomedical & Pharmacology Journal
Volume
2
Issue
19
Start Page
1727
End Page
1727
ISSN
0974-6242
2456-2610
Хураангуй
Gentamicin-induced acute kidney injury (AKI) causes tubular damage and activates inflammatory pathways, including p38 MAPK, which regulates cellular stress and inflammation. This study assessed the phenolic compound profile, safety, and nephroprotective effects of Taraxacum officinale extract in an experimental model of AKI. Phenolic compounds, specifically flavonoids and phenolic acids, were identified by thin-layer chromatography and quantified spectrophotometrically. Acute toxicity was measured by the Prozorovsky method. AKI was induced in Wistar rats with gentamicin (100 mg/kg), followed by oral administration of T. officinale extract (44 or 88 mg/kg) for 14 days. Kidney function, kidney injury molecule-1 (KIM-1), and activated p38 levels were measured to evaluate inflammation and renal protection. The extract contained luteolin, quercetin, apigenin, and caffeic acid. Total flavonoid content was expressed as luteolin equivalents (2.464 ± 0.24%). The LD50 (2.19 g/kg) showed low acute toxicity. Gentamicin raised serum creatinine, KIM-1, and p38 (p < 0.01), while 88 mg/kg extract reduced creatinine (−49.7%), KIM-1 (−14.3%), and p38 (−19.4%) (p < 0.05–0.01). Histopathology confirmed renal protection. These results demonstrate that T. officinale confers dose-dependent renoprotection, likely by reducing inflammation through flavonoid-mediated suppression of p38 MAPK signaling, which limits downstream production of pro-inflammatory mediators and renal cell injury.