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Antioxidant Effect of GOYO-11 Against Aspirin-Induced Gastric Ulcer in Rats
Он
2021 оны долоодугаар сарын 1
Төрөл
journal article
Хэвлэгч
Mongolian National University of Medical Sciences
Journal
Central Asian Journal of Medical Sciences
Volume
7
Issue
2
Start Page
131
End Page
138
ISSN
2413-8681
2414-9772
Хураангуй
Objectives: This study aimed to investigate the protective effects of GOYO-11 on aspirin-induced gastric ulcer formation. Methods: The prevention of aspirin-induced gastric ulcers was studied in 60 rats divided into 6 equally sized groups: healthy group (no aspirin), control group (aspirin-only), standard drug group (aspirin + omeprazole and bismuth), GOYO-11 (aspirin + GOYO-11 50 mg/kg, 100 mg/kg, 150 mg/kg, respectively). Results: The aspirin-only control group had distinctly attenuated activities of superoxide dismutase, catalase, glutathione peroxidase compared to the healthy group (p < 0.05). The control group showed a significant elevation in malondialdehyde levels compared to the healthy group (p < 0.05). The GOYO-11 high dose group had a significant elevation in superoxide dismutase levels compared to the control group (p < 0.05). The GOYO-11 middle dose group showed significant elevation in catalase, superoxide dismutase, glutathione peroxidase levels compared to the control group with a significant reduction in malondialdehyde level when compared to the control group (p < 0.05). Conclusions: GOYO-11 had a gastroprotective effect against aspirin-induced gastric ulcer rats and probably prevents ulcers by protecting the antioxidants, inhibiting lipid peroxidation (malondialdehyde), saving mucous glycoprotein, and decreasing the infiltration of inflammatory cells.