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Dansran, Purevsuren

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Товч нэр
Dansran, Purevsuren
Бүтэн нэр
Dansran Purevsuren
Латин нэр
Dansran Purevsuren
Албан тушаал
Судлаач
Харьяалал

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    Alterations in Interleukin-6 and Other Parameters during Open-Heart Surgery
    (Mongolian National University of Medical Sciences, 2017-02-25)
    Chultemdarjaa, Tuvjargal
    ;
    Ganbaatar, Undarmaa
    ;
    Batjargal, Sodgerel
    ;
    Nachin, Baasanjav
    ;
    Artbazar, Bayarzaya
    Objectives: Cardiopulmonary bypass (CPB) using a heart-lung machine to perform open-heart surgery is known to be associated with numerous pathophysiologic changes in body systems. Soon after beginning extracorporeal circulation, an activation process of certain plasma protein systems occurs as blood contacts the foreign surfaces of the cardiopulmonary bypass circuit. During cardiac surgery with CPB, there is a systemic inflammatory reaction involving an enhanced release of inflammatory cytokines. In this study, we investigated the occurrence of systemic inflammatory response syndrome (SIRS) and the mechanisms that lead to the protraction of SIRS in patients who are operated under CPB. Methods: Blood samples from 27 patients (12 females and 15 males, aged 18-63 years) who underwent CPB were collected before and at several time points after surgery and analyzed for plasma levels of proinflammatory cytokines and white blood cells (WBC). Results: In patients with SIRS, the duration of CPB, interleukin-6 (IL-6) count, and WBC count after aortic declamping were significantly higher. The occurrence of SIRS was significantly correlated with the highest recorded level of IL-6 (OR 1.01, 95% CI 1.00-1.01, p<0.05) and the duration of CPB (r = 0.578, p<0.001). Conclusion: The study findings suggest that the duration of CPB and cytokinemia characterized by high IL-6 levels may play an important role in the development of the SIRS.
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    Serum Lipid Profile and Its Association with Hypertension among Mongolian Adults
    (Mongolian National University of Medical Sciences, 2018-09-25)
    Bayart, Nandin-Erdene
    ;
    Batsaikhan, Saruuljavkhlan
    ;
    Yondonjamts, Pilmaa
    ;
    Dansran, Purevsuren
    ;
    Lkhaasuren, Galsumiya
    Objective: The purpose of this study was to investigate the relationship between serum lipid profile and hypertension among Mongolian adults. Methods: This population-based cross-sectional study was conducted between January and June 2018 in Mongolia. According to current European Society of Cardiology guidelines, hypertension was defined as an average systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg. Lipid profile (total cholesterol (TC), triglycerides (TG), high-density lipid [HDL], cholesterol and low-density lipid [LDL]-cholesterol) and fasting plasma glucose as well as Apolipoprotein B (ApoB), Apolipoprotein A (ApoA) and a ratio of apoB/apoA1 were estimated. Results: This study included 998 participants with a mean age ± SD of 49.4±14.8 years. Serum levels of TC, TG, and LDL were 4.8±0.93, 1.58±1.19 and 3.23±0.9 mmol/L, respectively among males, and 4.5±0.96, 1.22±0.48 and 2.95±1, respectively in females, which were significantly lower (p<0.05). The serum HDL was significantly lower (p<0.01) in males (1.67±0.22mmol/L) than in females (1.85±0.21). Conclusion: The results of this study demonstrate that people with hypertension are more likely have higher dyslipidemia, including elevated TC, TG, LDL and reduced HDL cholesterol level compared to a normotensive group. However, according to the binary logistic regression analysis, the most significant elevations of BP were attributed to age and reduced HDL.