Lkhagvasuren, Nasantsengel
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Товч нэр
Lkhagvasuren, Nasantsengel
Бүтэн нэр
Lkhagvasuren Nasantsengel
Латин нэр
Lkhagvasuren Nasantsengel
Албан тушаал
Судлаач
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Item type:Publication, Main characteristics of dermatoglypics associated with schizophrenia and its clinical subtypes(2021); ; Dermatoglypic patterns are extensively investigated to apply in disease-related risk assessment due to an obvious association between morphological and genetic characteristics. In the current study, we aimed to determine whether the fingerprint and palmar patterns vary between case population with schizophrenia and general population. A cross sectional study was conducted in people diagnosed with schizophrenia (cases) and a control population between 2016 and 2019. In this study, 252 people were participated. Ink and paper method was used to evaluate the difference of fingerprints palm prints between patients with schizophrenia and participants in control group.93 participants were analyzed in schizophrenic group and 142 participants were investigated in the control group. The percentage of arches on the right ring finger was significantly different between the schizophrenic patient group and control group (p = 0.011). The whorl pattern type (U-W-U-W-W-W-W-U-W-U) was dominantly observed in both of the schizophrenic patient group and control group. A-B ridge count in schizophrenic patient group and control group produced a markedly significant difference (p<0.05). Interestingly, a strong significant difference was produced in comparing of A-B ridge count in catatonic schizophrenia group with residual schizophrenia group (p<0.005). In comparison, index of pattern intensity in control group was slightly higher than that in schizophrenic patient group. Taking together, these results showed that the dermatoglypic characteristics might be a valuable tool to describe the nature of schizophrenia and its clinical subtypes and further studies are needed in clinical application.Scopus© Citations 7 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Synergistic SNP-SNP interaction of NRG1 and ERBB4 increases the risk of schizophrenia(2025-09); ; In last two decades, quite of few evidences were found about the genetic risk factor for schizophrenia. But until now, it's poorly understood that the pathogenesis of schizophrenia and contribution of those genetic factors in it. Inconsistent data reported for several candidate gene polymorphisms contributing on schizophrenia development, previously. The case-control study was conducted with 102 schizophrenia patients and 150 control subjects. HTR2A (rs6311), TPH2 (rs1386494), NRG1 (rs3924999 and rs2954041), DISC1 (rs821616 and rs6675281) and ERBB4 (rs7424835 and rs4673628) gene polymorphisms were detected by allele specific PCR and RFLP. Genetic analysis were performed by SNPAlyze 9.0 and STATA 13.0 software. Also, multidimensional regression analysis was used to determine the SNP-SNP interaction. T allele of rs821616 DISC1 and G allele of rs4673628 ERBB4, were associated with increased risk of schizophrenia. Significant difference was observed for heterozygous G/A genotype of rs6311 (G/A vs G/G + A/A, OR = 2.11; 95 % CI, 1.25-3.54, p = 0.005). By SNP-SNP interaction, the cumulative effect of NRG1 (rs3924999) and ERBB4 (rs4673628) combination, had increasing the risk of schizophrenia by 9.44-fold. This data require independent replication for rs821616, rs4673628 and rs6311 polymorphisms and schizophrenia risk. But particularity, our result suggests the interaction, rs3924999-rs4673628 of NRG1 and ERBB4 genes surprisingly increases the risk of schizophrenia.Scopus© Citations 1