Chuluun-Erdene, Ariunbold
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Chuluun-Erdene, Ariunbold
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Chuluun-Erdene Ariunbold
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Chuluun-Erdene Ariunbold
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Судлаач
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Item type:Publication, Adiponection/Leptin Ratio and Insulin Resistance among Mongolians with Metabolic Syndrome(Mongolian National University of Medical Sciences, 2018-03-25); ; Objectives: In this study, we aimed to determine the relationship between adiponectin/leptin (A/L) ratio and insulin resistance among Mongolian subjects with metabolic syndrome (MetS). Methods: The study was comprised of 364 adults. Fasting blood glucose, total cholesterol, triglyceride, and high density lipoprotein cholesterol were measured. Serum adiponectin and leptin were measured using enzyme-linked-immunoassay. Low density lipoprotein cholesterol and homeostatic model assessment-insulin resistance (HOMA-IR) were calculated. Results: Serum adiponectin was inversely correlated with diastolic blood pressure, body mass index, waist circumference, serum triglyceride, and fasting insulin level (r=-0.118, r=-0.190, r=-0.244, r=-0.231, and r=-0.165, respectively) (p<0.001). Serum leptin was significantly correlated with all risk factors of metabolic syndrome, except for lipid parameters (p<0.001). In the multiple regression analysis, HOMA-IR was significantly associated with adiponectin and A/L ratio among males with MetS, after adjustment for other factors. Conclusion: The A/L ratio was a significant predictor for insulin resistance among male adults with MetS. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Higher Leptin Level among Mongolians with Metabolic Syndrome as a Predictor of Cardiovascular Risk(Mongolian National University of Medical Sciences, 2017-02-25); ; Objectives: The focus of our research was to determine and identify the cutoff level of leptin in Mongolian adults with metabolic syndrome (MS). Methods: This observed case-controlled study was performed with 259 adults (mean age 40.35±10.75; range 18-71 years old). A questionnaire and anthropological measurements were used for obtaining data. Fasting blood sugar, serum triglyceride, total cholesterol, HDL, adiponectin, leptin, and insulin were measured in fasting blood together with LDL and HOMA-IR calculations. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. Results: Average leptin levels of the group with MS were 10.97±11.32 ng/ml and 23.86±11.32 ng/ml in males and females, respectively. The average leptin level of participants with MS was 17.23±1.59 ng/ml, which was significantly higher than the control group by 10.80±1.58. The MS exposed group had a much higher level of leptin than the control group (p<0.001). Leptin was the predictor of MS in both sexes (AUC-0.839, p<0.0001 for men and AUC-0.737, p<0.0001 for women). Conclusion: Leptin levels in the MS exposed group were higher than in the control group. Leptin may be a useful biomarker of cardiovascular risk in Mongolian adults. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Leptin Gene G2548A Polymorphism among Mongolians with Metabolic Syndrome(2018-12); ; Metabolic syndrome (MetS) corresponds with multiple risk factors. Many studies have indicated that MetS significantly increases the risk of cardiovascular diseases and type 2 diabetes (T2D). The prevalence of MetS was estimated to be one third of the general Mongolian population in 2015. The purpose of our study was to determine polymorphisms of the LEP (Leptin) and LEPR (Leptin receptor) genes that show susceptibility to MetS and to predict the genetic risk of MetS. We selected 160 cases with MetS and 144 with healthy controls. The G2548A polymorphism of the LEP gene and the A668G (Q223R) polymorphism of the LEPR gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results of the regression analysis showed that the 2548 amino acids (AA) of LEP gene carriers had increased incidences of MetS (OR = 3.23; p = 0.035), and the combined genotype AA/AA of LEP and LEPR gene polymorphisms was related to the development of MetS (OR = 3.73; p = 0.047). Patients with MetS who were 2548A allele carriers had an increased concentration of serum leptin (p = 0.011). Moreover, G2548A of LEP polymorphism was associated with elevated body mass index (BMI) and fasting blood glucose (FBG) in the case group. Our results confirm that the LEP G2548A loci is the independent risk factor of MetS.Scopus© Citations 10