Byambadorj, Bayarlakh
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Товч нэр
Byambadorj, Bayarlakh
Бүтэн нэр
Byambadorj Bayarlakh
Латин нэр
Byambadorj Bayarlakh
Албан тушаал
Судлаач
ORCID
6 results
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Item type:Publication, Detection and antibiotic resistance of diarrheagenic Escherichia coli from patients with diarrhea in Ulaanbaatar, Mongolia(2023-02); ; Scopus© Citations 8 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Scopus© Citations 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Identification of Staphylococcus aureus Causing Contamination in Raw Beef and Meat-Processing Environments in Ulaanbaatar, Mongolia(2025); ; Staphylococcus aureus (S. aureus) is a Gram-positive bacterium capable of causing a range of infections and displaying significant antibiotic resistance. S. aureus can exhibit resistance to multi-antibiotics, particularly penicillin, methicillin, linezolid, and daptomycin. The prevalence of methicillin-resistant S. aureus (MRSA) ranges from 10%-50% in China and Russia, neighboring countries of Mongolia. This study aimed to assess S. aureus contamination in raw beef samples and surface swabs from meat-processing areas and markets, while detecting, as well as to detect virulence and resistance genes in the isolates. A total of 156 raw beef samples and 131 surface swabs were collected and analyzed using ISO 6888-1:2021 standards. The nucA gene specific to S. aureus was amplified by PCR, and antibiotic susceptibility was evaluated using the Kirby-Bauer disk diffusion method. Resistance genes (mecA, mecC, vanA, and vanB) and virulence genes (sea, sed, tsst, eta, and etb) were detected via PCR. The results showed contamination rates of 26.9% in raw beef and 15.3% in surface swabs. The isolates exhibited high resistance to oxacillin, ampicillin, and penicillin in meat samples and to oxacillin, tetracycline, azithromycin, and clindamycin in surface swabs. No resistance genes for vancomycin or methicillin (mecC, vanA, vanB) were detected. Virulence genes, including tsst (14.5%), sea and etb (9.7%), eta (3.2%), and sed (1.6%), were identified. Contamination was more prevalent in centers responsible for both transportation and sales, compared to meat-processing areas. These findings highlight the need for stricter hygiene and handling practices in meat transport and markets to reduce S. aureus contamination and limit the spread of resistant strains.Scopus© Citations 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The polymorphisms of TSHR and CTLA-4 genes as genetic predictors of susceptibility to Graves` ophthalmopathy(Informa UK Limited, 2026-04); ; ; ; PURPOSE: To determine the genetic polymorphisms of CTLA-4 and TSHR genes with susceptibility to Graves` ophthalmopathy among patients with Graves' disease. METHODS: A total of 187 patients with Graves' disease were divided into two groups: 87 with Graves` ophthalmopathy and 100 without. Clinical examination and thyroid function tests were performed for all patients with Graves` disease. The genotyping was performed by restriction fragment length polymorphism and allele-specific PCR methods. RESULTS: rs5742909 T and rs1054708 T alleles were frequent in the group with Graves` ophthalmopathy. By genotypic comparison, the T/T and C/T genotypes of rs5742909 and the T/T genotype of rs1054708 were significantly higher among patients with Graves` ophthalmopathy. In addition, we found more than additive interaction between rs5742909 and rs1054708 (RERI = 3.787, AP = 0.122, S = 1.16), and the patients who carrying T/T or C/T of rs5742909 and T/T of rs1054708 had significantly higher risk of Graves` ophthalmopathy (aOR = 8.77, 95% CI = 3.02-25.52; Power = 98.1%). CONCLUSIONS: This result indicates that rs5742909 of CTLA-4 and rs1054708 of TSHR genes are the genetic risk factors for Graves` ophthalmopathy. In addition, the combination of these polymorphisms might be used as genetic predictors of Graves' ophthalmopathy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Detection of virulence genes of Staphylococcus aureus isolated from raw beef for retail sale in the markets of Ulaanbaatar city, Mongolia(2023-11); Scopus© Citations 16 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The synergistic interaction between ACE and TMPRSS2 polymorphisms increases the risk of severe COVID-19(Public Library of Science (PLoS), 2026); ; ; Within a few years after the pandemic outbreak, several of evidence have found to suggest that the genetic factors influence the severity and mortality rate of COVID-19. In particular, the identification of genetic markers that increase the risk of severe or critical COVID-19 is important for public health management during the pandemic. By August 2021, 88.9% of Mongolian population had been vaccinated. Therefore, we conducted this study to compare the polymorphisms of candidate genes by selecting people who developed mild or severe COVID-19 within this vaccinated population. A total of 90 patients with severe COVID-19, 95 patients with mild COVID-19, and 90 asymptomatic patients were participated in present cross-sectional study. rs4646994, rs4240157, rs41423247, rs56149945, rs10052957, rs12329760, rs4303795, rs75603675 and rs17854725 polymorphisms of the ACE, ACE2, NR3C1 and TMPRSS2 genes were genotyped. Genotyping performed by real-time PCR, RFLP and allele-specific PCR methods. Odds ratio, 95% confidence interval, p value were calculated using logistic regression analysis. SNP-SNP interaction were explored using multi-dimensional reduction analysis. P values for multivariate model was corrected by Bonferroni correction. Totally 10 polymorphisms of above-mentioned genes were genotyped among the groups. Only A/C genotype frequencies of rs75603675 were significantly different between groups. Compared with mild COVID-19 group, the participants who carrying A/C genotype of rs75603675 had 3.58-fold (95% CI, 1.38-9.29, p = 0.009) higher risk for severe COVID-19. In addition, the synergistic interaction (RERI = 2.573; AP = 0.934; S = 8.352) was observed between D/D or I/D genotype of rs4646994 and A/C genotype of rs75603675, which combination (OR=4.88, 95% CI, 1.38-18.01, p = 0.014, Power = 91.1%) was associated with increased risk of severe COVID-19 after Bonferroni correction. Our result suggesting that the combination of rs4646994 of the ACE gene and rs75603675 of the TMPRSS2 gene is associated with increased risk of severe COVID-19.