Erdenebat, Khaliun
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Товч нэр
Erdenebat, Khaliun
Бүтэн нэр
Erdenebat Khaliun
Латин нэр
Erdenebat Khaliun
Албан тушаал
Судлаач
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Item type:Publication, Determining the Cardioprotective Effect of Mongolian Medicine Shaosha-7 by Expression of Bcl-2 and Bax Proteins(2024-08-16); ; Background: Ischemia/reperfusion (I/R) plays an imperative role in the expansion of cardiovascular disease. Shaosha-7 has been exhibited to possess antioxidant, anti-inflammatory, antiaggregant, and vasodilator properties. Shaosha-7, a combination of the traditional herb and Mongolian medicine, is effective and safe in treating atherosclerosis in clinical trials. We assess the cardioprotective effects of Shaosha-7 against myocardial ischemia and reperfusion (MI/R) injury in rats and explore its possible mechanism. Methods: Seventy male Sprague Dawley rats were randomized into seven groups, 10 rats in each: normal healthy group (NG), non-MI/R group (Sham), MI/R injury group (Control group) were treated with 2 ml/100 g distilled water, once a day for 15 days and, MI/R group treated with a low, medium, high dose of Shaosha-7 at the doses of 0.4, 0.8 and 1.6 g/kg (Drug group 1,2,3 ) respectively, once a day for 15 days, and MI/R group treated with 0.3 g/kg Danshen (Positive drug group), once a day for 15 days. MI/R was induced by ligation of the left anterior descending coronary artery (LAD) for 30 minutes, then the thoracic cavity was closed after reperfusion in the Control and Drug groups. In the Sham group, the LAD was exposed without occlusion. Blood samples were collected from the carotid artery (10 rats in each group) after 2 hours of reperfusion, to determine the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18), cardiac troponin I (cTnI), creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) using enzyme-linked immunosorbent assays. The expression of NF-кB was detected by immunohistochemistry. The animals were then sacrificed and the hearts were harvested for histopathology and western blot analysis. Infarct size was measured in the remaining five rats in each group after 24 hours of reperfusion. Results: Shaosha-7 significantly decreased levels of TNF-α, IL-1β, IL-6, IL-18, cTnI, CK-MB, LDH, MDA, GSH-Px, and infarct size through the upregulating the expression of BCL-2 protein and down-regulating the expression of Bax protein. Conclusions: Shaosha-7 is effective in protecting the myocardium against MI/R injury in rats. Its possible cardioprotective mechanism involves inhibition of the inflammatory response and apoptosis following MI/R injury. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats(Mongolian National University of Medical Sciences, 2024-09-30); ; ; Objective: The Qinggan-27 (QG-27) recipe is a traditional Mongolian medicine believed to improve liver function during Non-alcoholic steatohepatitis (NASH). We developed fatty liver models in rats by intragastric administration of a high-fat diet (HFD) to investigate the effects of the QG-27 recipe on the NASH model through the expression of PGC-1 α and UCP-2. Methods: Wister rats were fed with specially prepared HFD to create a pathological model for 6 weeks. After successful modeling, the patient was treated with QG-27 twice daily with intragastric administration of QG-27 at 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively, for 21 days. Biochemical, histopathological, and immunohistochemical analyses were conducted to evaluate the effect of QG-27 treatment. Results: Levels of AST, ALT, LDL-C, TG, and TC were significantly decreased, and HDL-C was increased in the intermediate dose of the QG-27 group compared to the control group (p<0.05). Immunohistochemical results demonstrated that an intermediate dose of the QG-27 recipe could significantly improve liver function in rats with fatty liver by increasing PGC-1α and UCP-2 expression. Conclusion: The intermediate (300 mg/ kg) dose of the QG-27 is a good candidate to be a dietary supplement for reducing fatty liver. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, KIMURA’S DISEASE: Presenting as unilateral parotid mass(Mongolian National University of Medical Sciences, 2023-09-30); ; ; Objectives: Kimura’s disease (KD), or eosinophilic lymphogranuloma, is a rare chronic inflammatory condition with unclear etiology. We aim to present our experience with this condition and review the available literature. Methods: This report depicts a pathologically proven case of KD in a 44-year-old man with gradually increased swelling in his left parotid region for the past year, which was painless, and pruritus. Results: This report depicts a pathologically proven case of KD in a 44-year-old man with gradually increased swelling in his left parotid region for the past year, which was painless, and pruritus. Conclusion: This report depicts a pathologically proven case of KD in a 44-year-old man with gradually increased swelling in his left parotid region for the past year, which was painless, and pruritus.