Даваа–Баасан 08:30–20:00 · Бямба 09:00–16:00
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    Effects of Mongolian Medicine Modified Sugmul-7 on Hyperplasia of the Breast
    (Mongolian National University of Medical Sciences, 2021-09-30) ; ; ;
    Tuul Khalzaibaast
    ;
    Gong Juhua
    Objectives: The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with Mongolian Medicine Modified Sugmul-7 (MMMS-7) by Proteomics and provide an experimental basis for its development and clinical application. Methods: Ninety female SD rats were randomly divided into 6 groups: the intact group – the animal group that was injected with neither estradiol, nor progesterone, nor administered Mongolian Medicine Modified Sugmul-7; the negative control group – the group injected with estradiol and progesterone; the positive control group - injected with estradiol, progesterone and administered mastodynon 0.06 g/kg; and the treatment groups – injected with estradiol and progesterone, each in their respective dose groups. After the start of the experiment, each rat except the intact group was intra peritoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3 mg / kg for a total of 31 days. Results: Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1, and Nmd3 and their 5 related pathways. Conclusions: The above pathways are all known to be related to the treatment of breast hyperplasia caused by endocrine disorders. Treatment with Mongolian Medicine Modified Sugmul-7 is completed through regulation of the gastrointestinal and endocrine systems.
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    Minimal Stimulation Using Gonadotropin Combined with Clomiphene Citrate or Letrozole for Intrauterine Insemination
    (Mongolian National University of Medical Sciences, 2022-12-29) ;
    Nasantogtokh Erdenebileg
    ;
    Enkhmaa Davaasuren
    ;
    ;
    Objective: In this study we aimed to evaluate the administration efficiency of first-line drugs such as clomiphene citrate (CC), letrozole (L), and the gonadotropin follicle stimulating hormone (FSH) to be used in ovulation induction for intra uterine induction (IUI) in Mongolian patients. Methods: In this prospective single center study we recruited 158 infertile women with polycystic ovarian syndrome (PCOS). Results: In the FSH group, 15 patients (31.2 %) had mycoplasma. On the other hand, the group CC and the L group had a significantly higher number of pregnancies compared than the FSH group. Moreover, there was a trend for an increasing volume of menstruation in the CC group. 38.6 % having a medium volume of menstruation, while 59.6 % had a big volume of menstruation. Stimulation characteristics of patients shows that estradiol on started day (SE2) was significantly higher in the FSH group (768.91 ± 575.64), while it was 523.66 ± 435.84 and 419.36 ± 326.30 in the CC and the L groups, respectively. Conclusions: A minimal stimulation protocol using FSH, CC and L separately was done in Mongolian women with polycystic ovarian syndrome (PCOS). Clinical pregnancy rates were 1.46 ± 0.50 in the FSH group, 1.35 ± 0.48 in CC group, and 1.38 ± 0.49 in L group.
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    Performance of Ovarian Response Prediction Index As Predictor of Ovarian Response
    (Mongolian National University of Medical Sciences, 2022-06-30) ;
    Nasantogtokh Erdenebileg
    ;
    Enkhmaa Davaasuren
    ;
    ;
    Objective: We aimed to evaluate potential predictors of response to controlled ovarian stimulation (COS), including follicle stimulating hormone (FSH), Estradiol, antral follicle count (AFC), and ovarian response prediction index (ORPI). Methods: In this prospective, single center study, we recruited 55 infertile women underwent the first cycle of in vitro fertilization/ intracytoplasmic injection/intrauterine insemination (IVF/ICSI/IUI). We measured serum FSH and anti-mullerian hormone (AMH) level by ELISA and evaluated AFC. In accordance with formula, AMH x AFC / patient's age, ORPI was calculated. Results: The study participants are aged between 25 to 48 in infertility women. The mean age of the participants are 34.5 ± 5.5. The hormonal predictors, as well as ovarian response, are presented in Table 2. Predict ovarian hypo response by E2 and ORPI. Multivariable models improved the predictive accuracy for hypo-response (AUC > 0.6). With regard to the hyper-response, ORPI, E2 and AFC showed good predictors. In the multivariable model, the ORPI, E2 and AFC presented the best predictive accuracy, with an AUC 0.81, a sensitivity of 87 %, and a specificity of 67 %. Conclusion: ORPIndex is predicting the hyper-response more accurately than the ovarian hypo- response in infertility women. Participant’s ovarian reserve biomarkers (AFC and E level) was significantly increased predictive accuracy.