Miegombo, Ambaga
Loading...
Товч нэр
Miegombo, Ambaga
Бүтэн нэр
Miegombo Ambaga
Латин нэр
Miegombo Ambaga
Албан тушаал
Судлаач
9 results
Now showing 1 - 9 of 9
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Study of Proton Loss Level in Models of Coronary Heart Disease Deficiencies in an Experimental Animals(Mongolian National University of Medical Sciences, 2021-04-01); ; ; Objectives: The objective, in this study is to create a pathological model of coronary heart disease in pneumonia, based on the new theory of membrane-redox potentials three-state line system-dependent -full 9 stepped cycle of proton conductance inside the human and animal body, to study the activity of respiratory dehydrogenase enzymes at the ischemic site, and the proton entry state formed by bicarbonate in the 8th stage of full chain for Traditional Medicine. Methods: The experimental model used in this study was a pathological model of myocardial ischemia as developed by Kogan and Ambaga in healthy white Wistar rats approximately weighing 200-250 ± 20g. Results: On days 3-21 of the experiment, we have observed that the proton entry formed bicarbonate decreased by 9.8-13.9% both within the red blood cell membrane surface and outside the red blood cell membrane during whole red blood cell lysis. Moreover, the level of proton depletion was high, but the unstained or cell respiration released area increased by 10.25-20.34% (p < 0.05). Conclusions: In the 8th stage ofthe full 9 stepped cycle closed chain of protons, the proton entry formed bicarbonate decreased in the red blood cell membrane surface, and ischemic standing nodule electron-proton leak and dehydrogenase enzyme activity was decreased significantly. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of Antischemin Preparations on Platelet Hyperactivity in Diabetic Rabbit Model(Mongolian National University of Medical Sciences, 2021-04-01); ; ; Objectives: We aim to investigate how antischemin preparation affects the platelet parameters in a rabbit model with alloxan induced diabetes. Methods: Rabbits were divided into 4 groups; group 1 or control group, group 2 or no antischemin group without medication, group 3 or experimental group and group 4 or comparing group. Specific parameters such as PLT, PWD, MPV, P-LCR and PCT concentration were measured on day 3, 7, 14, 21 and 28. Results: Treatment of the no antischemin group with 6% alloxan monohydrate only resulted in a significant increase of platelet level and reached the highest value at 28th days (336.5 ± 21.2). When animals pre-treated simultaneously with antischemin for 5 days, the level of platelets did not increase significantly, compared to that in the non-treated group. After treatment of this group with 6% alloxan monohydrate, at the end of the trial (28 day), the platelet level was 274.7 ± 6.2 g/L, and in the clopidogrel pre-treated group, it was 274 ± 13.9 g/L. In the non-treated group, during the first 21 days, alloxan monohydrate caused a slight increase in PDW levels. Conclusions: Numerous studies revealed that botanical extracts which have been widely used as medicinal agents show potent anti-diabetic activity. Due to the serious side effects or resistance on synthetic drugs that are used in diabetes, the approach of using herbal remedies could be a successful alternative to the currently available diabetic treatments. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Determining the Cardioprotective Effect of Mongolian Medicine Shaosha-7 by Expression of Bcl-2 and Bax Proteins(2024-08-16); ; Background: Ischemia/reperfusion (I/R) plays an imperative role in the expansion of cardiovascular disease. Shaosha-7 has been exhibited to possess antioxidant, anti-inflammatory, antiaggregant, and vasodilator properties. Shaosha-7, a combination of the traditional herb and Mongolian medicine, is effective and safe in treating atherosclerosis in clinical trials. We assess the cardioprotective effects of Shaosha-7 against myocardial ischemia and reperfusion (MI/R) injury in rats and explore its possible mechanism. Methods: Seventy male Sprague Dawley rats were randomized into seven groups, 10 rats in each: normal healthy group (NG), non-MI/R group (Sham), MI/R injury group (Control group) were treated with 2 ml/100 g distilled water, once a day for 15 days and, MI/R group treated with a low, medium, high dose of Shaosha-7 at the doses of 0.4, 0.8 and 1.6 g/kg (Drug group 1,2,3 ) respectively, once a day for 15 days, and MI/R group treated with 0.3 g/kg Danshen (Positive drug group), once a day for 15 days. MI/R was induced by ligation of the left anterior descending coronary artery (LAD) for 30 minutes, then the thoracic cavity was closed after reperfusion in the Control and Drug groups. In the Sham group, the LAD was exposed without occlusion. Blood samples were collected from the carotid artery (10 rats in each group) after 2 hours of reperfusion, to determine the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18), cardiac troponin I (cTnI), creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) using enzyme-linked immunosorbent assays. The expression of NF-кB was detected by immunohistochemistry. The animals were then sacrificed and the hearts were harvested for histopathology and western blot analysis. Infarct size was measured in the remaining five rats in each group after 24 hours of reperfusion. Results: Shaosha-7 significantly decreased levels of TNF-α, IL-1β, IL-6, IL-18, cTnI, CK-MB, LDH, MDA, GSH-Px, and infarct size through the upregulating the expression of BCL-2 protein and down-regulating the expression of Bax protein. Conclusions: Shaosha-7 is effective in protecting the myocardium against MI/R injury in rats. Its possible cardioprotective mechanism involves inhibition of the inflammatory response and apoptosis following MI/R injury. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of Antischemin Preparations on Hypoxia(Mongolian National University of Medical Sciences, 2021-04-01); ; ; Objectives: We have aimed to determine the anti-hypoxic action of antischemin, an active anti-inflammatory drug that protects brain cells from damage and death during cerebral hemorrhage and hypoxia. Methods: We have studied antischemin made from Astragalus membraneceus roots, Scutellaria baicalensis Georgi roots, and Gingko Biloba leaves denizen in Mongolia and compared its protective effect against hypoxia compared to each of its constituents alone 6 groups of 8 mice. Normobaric hypoxia resistance as well as tissue hypoxia resistance was determined. Results: For antischemin preparation 100 mg/kg, the tolerance of normobaric hypoxia was 42 minutes or 47.2% higher in the treatment group (p < 0.001), and the latent period of hypoxia was increased by 22.7% (p < 0.05). The period of hypoxia increased 32% (p < 0.001). Conclusions: Antischemin has been shown to make tissue more resistant to hypoxia and and have more anti-hypoxic activity than its constituents alone. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Зүрхний титэм судасны дутагдлын үед эсийн гэмтлийг тодорхойлох зарим үзүүлэлтийг судалсан дүн(2021-09-01) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Том навчит дэгд (Gentiana macrophylla Pall)-ийн дархлаа зүгшрүүлэх, үрэвслийн загварт үзүүлэх нөлөөг туршилтын амьтдын интерлейкин-10 цитокинтэй уялдуулан судалсан дүн(2021-09-01) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Туршилтаар үүсгэсэн тархины ишемийн үед Антишемин бэлдмэлийн биологийн зарим үйлдлийг судлах нь(2020-05-01); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Зүрхний титэм судасны дутагдлын үед эсийн гэмтлийн байдлыг морфометрийн болон гравиметрийн аргаар судалсан дүн(2020-05-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Тархинд хүчилтөрөгч дутмагших үед эс хамгаалах тогтолцооны зарим үзүүлэлтүүдэд “Aнтишемин” бэлдмэлийн нөлөө(2020-05-01); ;