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Anti-inflammatory and Lung Protective Effect of the Herbal Formulation on LPS-induced Acute Lung Injury Model
Зохиогч
Anand Altankhuyag
Khongor Bat-Erdene
Maralgua Avirmed
Turtushikh Damba
Tsengelmaa Jamiyan
Он
2026 оны зургаадугаар сарын 25
Төрөл
journal article
Хэвлэгч
Oriental Scientific Publishing Company
Journal
Biomedical & Pharmacology Journal
Volume
2
Issue
19
Start Page
1974
End Page
1974
ISSN
0974-6242
2456-2610
Хураангуй
Herbal products are considered important medicinal sources in both traditional medicine and modern pharmacology. Our study examined the lung-protective and anti-inflammatory properties of the herbal formulation in alipopolysaccharide (LPS)induced model of acute lung injury. Non-cytotoxic concentrations in cells were evaluated in vitrousing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and analysis of nitric oxide (NO) production. In our invivo study, acute lung inflammation was induced in experimental animals by LPS. Treatment with the herbal formulation notably decreased NO production, increased superoxide dismutase (SOD) levels, and reduced the protein levels of tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1). Furthermore, histopathological studies confirmed its protective effects against LPS-induced lung inflammation. Molecular docking revealed that glycyrrhizic acid and inulin interact strongly with TNF-α and HMGB1 proteins, supporting their potential to mediate the observed anti-inflammatory effects.In conclusion, the herbal formulation demonstrates anti-inflammatory and lung-protective properties, suggesting its potential efficacy in mitigating LPS-induced acute lung injury.