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The Potential Effect of Traditional Herbal Medicine on Bile Flow in CC14-Induced Liver Injury Model
Зохиогч
Он
2024 оны есдүгээр сарын 27
Төрөл
journal article
Хэвлэгч
Mongolian National University of Medical Sciences
Journal
Central Asian Journal of Medical Sciences
Volume
10
Issue
3
Start Page
115
End Page
122
ISSN
2413-8681
2414-9772
Хураангуй
Objective: To investigate whether the modified Mongolian traditional medicine Yaman Serdeg-3 (NYS-3) effects the biliary excretion in the carbon tetrachloride-induced liver injury model. Methods: Forty-seven male and female Sprague-Dawley rats were divided into 5 groups: Group I healthy group (n=12); Group II healthy group + NYS-3 (n=9); Group III liver injury model (n=10); Group IV liver injury model + Chinese medicine Hua gan Pian (n=10); Group V liver injury model + NYS-3. Experimental groups II-V, received corresponding medicinal preparations for 2 weeks. The dose of Hua gan Pian (HGP) was 0.046g/ml while the dose of NYS-3 was 2.025g/ml. For the acute induction of liver injury, the rats were orally administered 40% CCl4 in olive oil (4 ml/kg) twelve hours after the last administration of preparations. Results: At the first 15-minute interval, the highest bile flow was observed in Group II rats, which were administered NYS-3. This phenomenon continued at the second 15-minute interval, also. However, at the third 15-minute interval, the bile flow decreased sharply in Group II. On the other hand, in the liver injury model, untreated or pre-treated rats had significantly different bile flows. For example, in the first half of the experiment, both non-treated and HGP pre-treated groups had similar bile flow, while, the group pre-treated with NYS-3 had significantly low bile flow. Then, after 45 minutes of the experiment, the bile flow became similar amounts in both pre-treated groups. Conclusion: We conclude that the NYS-3 administration had increased the bile flow at 3rd 15min of interval, which is higher than positive control group where liver injury model rats received HGP.