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Assessment of Pharmacological Effects of Mongolian Medicinal Plant Adonis mongolica in Guinea Pigs in vivo and in vitro
Зохиогч
Izumi-Nakaseko Hiroko
Li Wei
Xin Cao
Nakamura Yuji
Ando Kentaro
Koichiro, Tanaka
Enkhsaikhan Azjargal
Gotov Choijamts
Purevjav Batkhuyag
Hagiwara-Nagasawa Mihoko
T. Naito Atsuhiko
Koike Kazuo
Sugiyama Atsushi
Он
2017 оны арван хоёрдугаар сарын 1
Төрөл
journal article
Хэвлэгч
National Institute of Informatics
Journal
Institutional Repositories DataBase (IRDB)
Volume
3
Issue
4
Start Page
131
End Page
141
Хураангуй
Background: Adonis mongolica (Ranunculaceae) is one of the endemic plants in Mongolia and has been used as a medicinal herb in Mongolian traditional medicine to treat patients with congestive heart failure showing tachycardia and edema. Although the plant has been empirically used in the last three decades, the precise information regarding its cardiovascular profile is still limited. Methods: We assessed the cardiohemodynamic and electrophysiological profile of the water-soluble extract of A. mongolica using the guinea pig in vivo model (n = 4) and in vitro preparation (n = 5 - 17). In addition, the onset mechanism of the extract-induced effects on the heart rate and blood pressure in vivo (n = 4), and the atrial rate and contractile force in vitro (n = 4 - 5) were pharmacologically analyzed. Results: The extract exerted the positive chronotropic, negative dromotropic, and vasopressor effects in addition to the proarrhythmic action in vivo. Meanwhile, it modestly decreased the atrial rate and aortic tension but increased the atrial contractile force in vitro. The pretreatment of dl-propranolol and prazosin significantly suppressed the positive chronotropic and vasopressor actions induced by the extract in vivo, indicating that the extract increased the sympathetic tone. Also, liquid chromatography-mass spectrometry analysis showed that water-soluble extract of A. mongolica contained eight kinds of cardiac glycosides. Conclusions: These results indicate that cardiac glycosides in the water-soluble extract of A. mongolica may explain currently observed various cardiovascular effects.