Batkhuyag, Purevjav

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The clinical features and antibiotic susceptibility of causative bacters of pyelonephritis of children in Mongolia
(Japanese Pharmacological Society, 2018-01-01)
Khaliun Nyambayar
;
Batkhuyag Purevjav
;
Dashiima Luvsansuren
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Preventative Effect of Traditional Medicine Anar-5 on the Development of Chronic Gastritis in a Rat Model
(Mongolian National University of Medical Sciences, 2018-03-25)
Dashzeveg, Uranzaya
;
Buyantogtokh, Dejidmaa
;
Adilbish, Altanchimeg
;
Chimedtseren, Chimedragchaa
;
Purevjav, Batkhuyag
Objective: To study the effect of traditional medicine Anar-5 on the development of chronic gastritis in rat gastric mucosa. Methods: Rats were orally administered deoxycholate sodium 1ml/100 gm or a combination of deoxycholate 1 ml/100 gm and Anar-5 at Anar-5 100 mg/kg or 200 mg/kg for 4, 8, and 12 weeks to determine the protective effect of Anar-5. Serum gastrin levels were measured to determine the impact of Anar-5. Gastric specimens were prepared for light microscopy with hematoxylin and eosin and PAS stains. The damage of barrier in mucosa with erosion or ulceration, and the thickness of mucin were examined using light microscopy. The serum levels of gastrin were measured with ELISA method. Results: Under light microscopy, the gastric mucosa was diffusely eroded or ulcerated and the thickness of mucin was decreased in rats not treated with Anar-5. The levels of gastrin in serum were significantly lower in chronic atrophic gastritis rats than that in normal rats (p<0.05). Doubling the dose of Anar-5 from 100 mg/kg to 200 mg/kg made no difference. Conclusion: Treatment with Anar-5 prevented chronic gastritis and gastric atrophy.
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Assessment of Pharmacological Effects of Mongolian Medicinal Plant Adonis mongolica in Guinea Pigs in vivo and in vitro
(National Institute of Informatics, 2017-12-01)
Izumi-Nakaseko Hiroko
;
Li Wei
;
Xin Cao
;
Nakamura Yuji
;
Ando Kentaro
Background: Adonis mongolica (Ranunculaceae) is one of the endemic plants in Mongolia and has been used as a medicinal herb in Mongolian traditional medicine to treat patients with congestive heart failure showing tachycardia and edema. Although the plant has been empirically used in the last three decades, the precise information regarding its cardiovascular profile is still limited. Methods: We assessed the cardiohemodynamic and electrophysiological profile of the water-soluble extract of A. mongolica using the guinea pig in vivo model (n = 4) and in vitro preparation (n = 5 - 17). In addition, the onset mechanism of the extract-induced effects on the heart rate and blood pressure in vivo (n = 4), and the atrial rate and contractile force in vitro (n = 4 - 5) were pharmacologically analyzed. Results: The extract exerted the positive chronotropic, negative dromotropic, and vasopressor effects in addition to the proarrhythmic action in vivo. Meanwhile, it modestly decreased the atrial rate and aortic tension but increased the atrial contractile force in vitro. The pretreatment of dl-propranolol and prazosin significantly suppressed the positive chronotropic and vasopressor actions induced by the extract in vivo, indicating that the extract increased the sympathetic tone. Also, liquid chromatography-mass spectrometry analysis showed that water-soluble extract of A. mongolica contained eight kinds of cardiac glycosides. Conclusions: These results indicate that cardiac glycosides in the water-soluble extract of A. mongolica may explain currently observed various cardiovascular effects.

Batkhuyag, Purevjav

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