Batjargal, Ochbadrakh
Loading...
Товч нэр
Batjargal, Ochbadrakh
Бүтэн нэр
Batjargal Ochbadrakh
Латин нэр
Batjargal Ochbadrakh
Албан тушаал
Судлаач
ORCID
7 results
Now showing 1 - 7 of 7
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, ADRB2 and ACE Gene Polymorphisms in COPD Susceptibility(Mongolian National University of Medical Sciences, 2016-11-25); ; Objectives: Recent studies have established that rs1042713 and rs1042714 polymorphisms in the ADRB2 and rs4646994 in the ACE gene may have an influence on chronic obstructive pulmonary disease (COPD) development and its severity. The aim of this study was to investigate the association of ACE and ADRB2 gene polymorphisms with COPD. Methods: 100 patients with COPD and 100 healthy volunteers were randomly involved in this case-control study. The gene polymorphisms were identified by polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis. Results: No significant differences were observed for allele and genotype frequencies of the rs4646994 polymorphism in the ACE gene between case and control groups (p > 0.05). Genotype frequencies of Gly/Gly16 (OR = 2.31, 95% CI = 1.23-4.32, p = 0.027) and Gln/Gln27 (OR = 2.04, 95% CI = 1.14-3.63, p = 0.044) of the ADRB2 gene were more prevalent in COPD patients than the controls. Also, the proportion of the Gly16+Gln27 haplotype was statistically different between both groups (OR = 2.62, 95% CI: 1.65-4.15, p<0.001) Conclusion: There is no relation between the rs4646994 polymorphism in the ACE gene and COPD, but the homozygote Gly/Gly16 and Gln/Gln27 variations of the ADRB2 gene may increase the carrier’s susceptibility to the development of COPD. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Цар тахлын эхэн үед Монгол улсад голомтлон тархсан SARS-CoV-2-ийн удмын хэв шинжийг тодорхойлсон дүн(2023-02-16); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Монгол хүний удамзүйн судалгаануудын тойм(2023-05-18); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The genetic analysis of eight families with hemophilia B in Mongolia: Identification of two novel mutation(2024-09); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SARS-CoV-2 seroepidemiology in Mongolia, 2020-2021: a longitudinal national study(Elsevier BV, 2023-04); ; Scopus© Citations 6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, SARS-CoV-2 seroprevalence in Mongolia: Results from a national population survey(Elsevier BV, 2021-12); ; ; BACKGROUND: With the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in early 2020, Mongolia implemented rapid emergency measures and did not report local transmission until November 2020. We conducted a national seroprevalence survey to monitor the burden of SARS-CoV-2 in Mongolia in the months surrounding the first local transmission. METHODS: During October-December 2020, participants were randomly selected using age stratification and invited for interviews and blood samples at local primary health centres. We screened for total SARS-CoV-2 antibodies, followed by two-step quantitative SARS-CoV-2 IgG serology tests for positive samples. Weighted and test-adjusted seroprevalences were estimated. We used chi-square, Fisher's exact and other tests to identify variables associated with seropositivity. FINDINGS: A total of 5000 subjects were enrolled. We detected SARS-CoV-2 IgG antibodies in 72 samples. Crude seroprevalence of SARS-CoV-2 antibodies was 1·44% (95%CI,1·21-1·67). Population weighted and test-adjusted seroprevalences were 1·36% (95%CI,1·11-1·63) and 1·45% (95%CI,1·11-1·63), respectively. Age, sex, geographical, and occupational factors were not associated with seropositivity (p>0·05). Symptoms and signs within past 3 months and seropositivity were not associated at the time of the survey (p>0·05). INTERPRETATION: SARS-CoV-2 seroprevalence in Mongolia was low in the first year of the pandemic potentially due to strong public health measures, including border restrictions, educational facilities closure, earlier adoption of mask-wearing and others. Our findings suggest large-scale community transmission could not have occurred up to November 2020 in Mongolia. Additional serosurveys are needed to monitor the local pandemic dynamic and estimate how far from herd immunity Mongolia will be following-up with vaccination programme in 2021 and 2022. FUNDING: World Health Organisation, WHO UNITY Studies initiative, with funding by the COVID-19 Solidarity Response Fund and the German Federal Ministry of Health (BMG) COVID-19 Research and development. TRANSLATION: Cyrillic and Traditional Mongolian translation of abstract is available on appendix section.Scopus© Citations 14 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Molecular epidemiology of SARS-CoV-2 in Mongolia, first experience with nanopore sequencing in lower- and middle-income countries setting(Wiley, 2023-12); ; ; ; Burged, NatsagdorjBACKGROUND: Coronavirus disease (COVID-19) has had a significant impact globally, and extensive genomic research has been conducted on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage patterns and its variants. Mongolia's effective response resulted in low prevalence until vaccinations became available. However, due to the lack of systematically collected data and absence of whole genome sequencing capabilities, we conducted a two-stepped, nationally representative molecular epidemiologic study of SARS-CoV-2 in Mongolia for 2020 and 2021. METHODS: We used retrospective analysis of stored biological samples from November 2020 to October 2021 and a variant-specific real-time reverse transcription polymerase chain reaction (RT-PCR) test to detect SARS-CoV-2 variants, followed by whole genome sequencing by Nanopore technology. Samples were retrieved from different sites and stored at -70°C deep freezer, and tests were performed on samples with cycle threshold <30. RESULTS: Out of 4879 nucleic acid tests, 799 whole genome sequencing had been carried out. Among the stored samples of earlier local transmission, we found the 20B (B.1.1.46) variant predominated in the earlier local transmission period. A slower introduction and circulation of alpha and delta variants were observed compared to global dynamics in 2020 and 2021. Beta or Gamma variants were not detected between November 2020 and September 2021 in Mongolia. CONCLUSIONS: SARS-CoV-2 variants of concerns including alpha and delta were delayed in circulation potentially due to public health stringencies in Mongolia. We are sharing our initial experience with whole genome sequencing of SARS-CoV-2 from Mongolia, where sequencing data is sparse.Scopus© Citations 1