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Оюутнуудын дунд ядралтын төвшин, өдрийн цагаар нойрмоглох байдал, тэдгээрийн хамаарлыг судалсан нь
Зохиогч
Он
2024 оны дөрөвдүгээр сарын 13
Төрөл
journal article
Journal
Эрүүл мэндийн шинжлэх ухаан
Volume
20
Issue
4
Start Page
46
End Page
48
ISSN
2959-6947
Хураангуй
Үндэслэл: Өдрийн цагаар нойрмоглох болон ядралтын төвшин өндөр байх нь хувь хүний идэвх, өрсөлдөх чадвар, оюуны болон хөдөлмөрийн бүтээмжид сөргөөр нөлөөлдөг. Ялангуяа улс орны хөгжилд оюутны оролцоо чухал тул тэдгээрийн ядралтын төвшин, нойрмоглох байдлыг судлах нь ач холбогдолтой юм. Зорилго: АШУҮИС-ийн оюутнуудын дунд ядралт, өдрийн цагаар нойрмоглох байдлыг судалж тэдгээрийн холбоо хамаарлыг тодорхойлоход оршино. Арга, аргачлал: Судалгааг нэг агшингийн загвараар хийж гүйцэтгэв. Үр дүн: Судалгаанд АШУҮИСийн суурь боловсролын дамжааны 187 оюутан (эрэгтэй n=82, эмэгтэй n=105) оролцсон ба судалгаанд хамрагдагсдын 78.1% нь өдрийн цагаар нойрмоглодог бол 66.3% нь ядаргааны төвшин эрүүл мэндэд нөлөөлөхүйц өндөр байна. Ядралтын төвшин хүйсийн хувьд эмэгтэйчүүдэд илүү тохиолдож байсан (p<0.001) ба хэвийн байгаа хүмүүсийн 87.3% нь тогтмол болон хааяа дасгал хөдөлгөөн хийдэг байна. Мөн судалгаанд хамрагдагсдын 86.1% нь ном уншиж байхдаа нойрмоглодог хэмээх үр дүн гарсан. Дүгнэлт: Судалгааны үр дүнд статистикийн үнэн магадлалтайн шалгуураар ядаргааны төвшин ба өдрийн цагаар нойрмоглох байдал нь хоорондоо хамааралтай (p<0.001) байна.
Background: In recent years, there has been a lot of research on the possibility of replacing antibiotic treatment, and MNB is considered suitable for use as an alternative to antibiotics because it inhibits the resistance of multidrug-resistant bacteria and has excellent antibacterial properties. According to health statistics for 2022 in Mongolia, 44,903 new cases of purulent skin inflammation were registered in outpatient reports and 1,745 new cases were reported in inpatient reports. Therefore, there is a great demand for medical plasters, and the need to carry out extensive research on the form of medical plasters containing nanoparticles and introduce them into production and use them for treatment is the basis of our research. Aim: The aim is to evaluate the effect of silver nanoparticles-containing drugs on the skin in vivo. Materials and methods: In our study, we used a transdermal patch containing silver nanoparticles, hair clipper, ketamine hydrochloride, 10% solution of formalin, pipette, test tube, prepared and blank slides, cover slips, Pair of tweezers, surgical scissors, forceps, sterile bipsy punch, syringes, alcohol pads, adult male BALB/c albino mice and other tools. Mice of (weight : 22±2 g) were used used in this study. Mice were divided into two groups(n=5) randomly, kept under periods of 12 hr light and 12 hr dark specific patogenic-free conditions. The mice were kept on standart pellet diet and water ad libitum for two weeks to be acclimatized prior to the investigation. 48 hours after using the first dose of the patch, replace it with a new patch. The experimental animals were divided into including control (normal saline), positive control MRSA patch (Korea), and experimental groups AgNPs (50mg/kg), AgNPs (75mg/kg) and AgNPs (100mg/kg) , or a total of 5 groups, and each group had 6 mice. Results: The dose of silver nanoparticles was calculated as 50mg/kg, 75mg/kg and 100mg/kg for BALB/c white mice (weighing 22±2 grams), and 1 piece transdermal patch was measured to contain 0.0012g, 0.0017g, and 0.0023g prepared. The prepared transdermal patch was stored in at room temperature. Day 0 photographs were taken immediately after the injury. The wound healing was investigated by capturing digital photographs on days 0,3,7,14 and 21 of the experiment. In order to evaluate healing performance, the induced wounds scar sizes were measured using Image G program. Among the animals, healing rate of treated mice with AgNPs (50 mg/kg), AgNPs (75 mg/kg) and AgNPs (100mg kg1) was significantly faster than mice treated with MRSA patch (made in Korea) and untreated. Topical application of AgNPs (75, 100 mg kg) and MRSA patch (made in Korea) increased the rate of wound healing significantly more than AgNPs (50 mg kg) and normal saline group. Wound healing in the AgNPs (50, 75, 100 mg kg ) and MRSA patch (made in Korea) groups were nearly complete in day 21 after wound induction, whilst the wound in mice of control groups had not been healed entirely. No side effects were observed on body weight, general health and behavior of animals during treatment. Conclusion: The wound healing action of silvered nanoplaster was directly dose-dependent, it was determined that the wound healing was faster at a dose of 100 mg/kg. Wounds heal faster than imported wound dressings.
Нэмэлт мэдээлэл
Бүрэн эх: https://journal.mnums.edu.mn/index.php/emsu/article/view/175
Эшлэл
C. Лхагвасүрэн, Б.Халиун, Д.Отгонцэцэг. Оюутнуудын дунд ядралтын төвшин, өдрийн цагаар нойрмоглох байдал, тэдгээрийн хамаарлыг судалсан нь. Эрүүл мэндийн шинжлэх ухаан. 2024;20(4):46-48.