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Э.Мөнхсоёл

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Эрхэмбаатар Мөнхсоёл

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Erkhembaatar Munkhsoyol

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Lysosomal Ca2+ Signaling is Essential for Osteoclastogenesis and Bone Remodeling
(2017-02)
Erkhembaatar, Munkhsoyol
;
Gu, Dong Ryun
;
Lee, Seoung Hoon
;
Yang, Yu-Mi
;
Park, Soonhong
Lysosomal Ca2+ emerges as a critical component of receptor-evoked Ca2+ signaling and plays a crucial role in many lysosomal and physiological functions. Lysosomal Ca2+ release is mediated by the transient receptor potential (TRP) family member TRPML1, mutations that cause the lysosomal storage disease mucolipidosis type 4. Lysosomes play a key role in osteoclast function. However, nothing is known about the role of lysosomal Ca2+ signaling in osteoclastogenesis and bone metabolism. In this study, we addressed this knowledge gap by studying the role of lysosomal Ca2+ signaling in osteoclastogenesis, osteoclast and osteoblast functions, and bone homeostasis in vivo. We manipulated lysosomal Ca2+ signaling by acute knockdown of TRPML1, deletion of TRPML1 in mice, pharmacological inhibition of lysosomal Ca2+ influx, and depletion of lysosomal Ca2+ storage using the TRPML agonist ML-SA1. We found that knockdown and deletion of TRPML1, although it did not have an apparent effect on osteoblast differentiation and bone formation, markedly attenuated osteoclast function, RANKL-induced cytosolic Ca2+ oscillations, inhibited activation of NFATc1 and osteoclastogenesis-controlling genes, suppressed the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs), and markedly reduced the differentiation of bone marrow-derived macrophages into osteoclasts. Moreover, deletion of TRPML1 resulted in enlarged lysosomes, inhibition of lysosomal secretion, and attenuated the resorptive activity of mature osteoclasts. Notably, depletion of lysosomal Ca2+ with ML-SA1 similarly abrogated RANKL-induced Ca2+ oscillations and MNC formation. Deletion of TRPML1 in mice reduced the TRAP-positive bone surfaces and impaired bone remodeling, resulting in prominent osteopetrosis. These findings demonstrate the essential role of lysosomal Ca2+ signaling in osteoclast differentiation and mature osteoclast function, which play key roles in bone homeostasis. © 2016 American Society for Bone and Mineral Research.
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Peucedanum japonicum Thunb. ethanol extract suppresses RANKL-mediated osteoclastogenesis
(2017-07)
Kim, Jeong-Mi
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Erkhembaatar, Munkhsoyol
;
Lee, Guem-San
;
Lee, Jin-Hyun
;
Noh, Eun-Mi
The constituents of Peucedanum japonicum Thunb. (PJ) exhibit biological and pharmacological activities, including anti-obesity, anti-oxidant and anti-allergic activities. The aim of the present study was to examine in vitro effects of PJ in RANKL-induced signaling pathways, which determine osteoclast differentiation. PJ ethanol extract (PEE) exhibited anti-osteoporotic activity by disrupting the phospholipase C (PLC)-Ca2+-c-Fos/cAMP response element-binding protein (CREB)-nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) signaling pathway during osteoclastogenesis. Murine bone marrow-derived macrophages (BMMs) were cultured and used to determine the effects of PJ in the receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclastogenesis. The effects of PEE in the RANKL-mediated signaling cascade were evaluated using a standard in vitro osteoclastogenesis system. PEE treatment of BMMs significantly reduced the number of RANKL-mediated tartrate resistant acid phosphatase (TRAP)-positive multinucleated cells (P<0.05 for 5 and 10 µg/ml PEE, P<0.01 for 25 and 50 µg/ml PEE), without cytotoxic effects. Furthermore, the expression of differentiation-related marker genes, including TRAP, Oscar, Cathepsin K, dendrocyte expressed seven transmembrane protein, ATPase H+ Transporting V0 Subunit D2 and NFATc1, were markedly suppressed. PEE induced a transient increase in free cytoplasmic Ca2+ ([Ca2+]i) mobilization via voltage-gated Ca2+ channels and PLC-sensitive pathways. Transient [Ca2+]i increase consequently resulted in the suppression of c-Fos, CREB and NFATc1 activities. These findings highlight the potential use of PJ in treating bone disorders caused by osteoclast overgrowth.
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Seroprevalence and risk factors of hepatitis E virus infection among Bactrian camel herders in Dornod Province, Mongolia
(Elsevier BV, 2026-06-23)
Batsukh Chultem
;
Enkhbaatar Batmagnai
;
Khuntsetseg Altangerel
;
Unurjavkhlan Tsogbadrakh
;
Davaasuren Nergui
Objectives Hepatitis E virus (HEV) is an emerging zoonotic pathogen that causes viral hepatitis worldwide. Several HEV genotypes have been reported in human and animal populations, and camel-associated HEV genotype 8 has been detected in Bactrian camels. This study aimed to determine anti-HEV immunoglobulin (Ig) G seroprevalence and associated risk factors among camel herders and non-herders in Dornod Province, eastern Mongolia. Methods A cross-sectional study was conducted in 2024–2025 among 276 participants, from three districts of Dornod Province, including 146 camel herders and 130 non-herders. Serum samples were tested for anti-HEV IgG using a commercial enzyme-linked immunosorbent assay kit. Sociodemographic, dietary, health, and environmental data were collected using structured questionnaires. Associations between HEV seropositivity and risk factors were analyzed using univariable logistic regression. Results Overall, 43 (15.6%) of 276 participants were positive for anti-HEV IgG. Seroprevalence was similar among camel herders and non-herders, with 23 (15.8%) of 146 camel herders and 20 (15.4%) of 130 non-herders testing positive. This difference was not statistically significant (χ² test, P = 0.933; Fisher's exact test, P = 1.000). Higher seropositivity was observed among older participants, particularly, those aged ≥ 60 years, and among participants who regularly consumed raw camel milk. Lower educational level and district of residence were also associated with HEV seropositivity. Conclusion Previous HEV exposure is present among residents of Dornod Province, Mongolia; however, seroprevalence did not differ significantly between camel herders and non-herders. Because this study was based on anti-HEV IgG detection only, the infecting HEV genotype could not be determined, and the findings should not be interpreted as evidence of HEV-8 infection specifically. Further molecular studies are needed to identify circulating HEV genotypes and clarify transmission pathways in pastoral communities.
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Clinical physiological interventions to enhance the performance of Mongolian basketball players
(Mongolian National University of Medical Sciences, 2026-03-30)
Erkhembaatar, Munkhsoyol
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Myagmarjav, Jadamba
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Munkhzaya, Khaliun
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Munkhbat, Batnyam
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Boldbaatar, Damdindorj
Objective: To evaluate certain neurophysiological parameters of basketball players, analyze the effects of aerobic and anaerobic training, and assess the role of nutrition and physical recovery. Methods: Seven male professional players (aged 19–25) from the Erdenet Miners team completed a two-month integrated intervention combining structured aerobic/anaerobic training, individualized nutrition plans, and recovery modalities. Assessments were conducted at baseline, mid-intervention, and post-intervention, measuring body composition, aerobic capacity, muscular strength, agility, pulmonary function, neuromuscular balance, and psychological recovery. Non-parametric tests (Friedman and Wilcoxon) were used to evaluate changes over time. Results: Significant improvements were observed across multiple domains. Body fat decreased from 21.6% to 19.6%, while muscle mass and protein levels increased. Aerobic capacity improved, including Cooper test performance (2.86 km to 3.22 km), Yo-Yo IR1 (1005 m to 1385 m), and MVV (156.2 to 184.9 L/min). Agility increased by 14%, vertical jump height by 6.1%, and muscular asymmetry declined. Psychological recovery (RestQ-Sport) also improved. Conclusions: A comprehensive neurophysiological intervention combining structured training, targeted nutrition, and advanced recovery techniques significantly enhanced physical performance, physiological efficiency, and psychological well-being in elite basketball players. These findings highlight the value of integrated performance-optimization strategies in improving individual and team outcomes.

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