Dorjkhuu, Amgalanbaatar
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Товч нэр
Dorjkhuu, Amgalanbaatar
Бүтэн нэр
Dorjkhuu Amgalanbaatar
Латин нэр
Dorjkhuu Amgalanbaatar
Албан тушаал
Судлаач
ORCID
23 results
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Item type:Publication, Study of Proton Loss Level in Models of Coronary Heart Disease Deficiencies in an Experimental Animals(Mongolian National University of Medical Sciences, 2021-04-01); ; ; Objectives: The objective, in this study is to create a pathological model of coronary heart disease in pneumonia, based on the new theory of membrane-redox potentials three-state line system-dependent -full 9 stepped cycle of proton conductance inside the human and animal body, to study the activity of respiratory dehydrogenase enzymes at the ischemic site, and the proton entry state formed by bicarbonate in the 8th stage of full chain for Traditional Medicine. Methods: The experimental model used in this study was a pathological model of myocardial ischemia as developed by Kogan and Ambaga in healthy white Wistar rats approximately weighing 200-250 ± 20g. Results: On days 3-21 of the experiment, we have observed that the proton entry formed bicarbonate decreased by 9.8-13.9% both within the red blood cell membrane surface and outside the red blood cell membrane during whole red blood cell lysis. Moreover, the level of proton depletion was high, but the unstained or cell respiration released area increased by 10.25-20.34% (p < 0.05). Conclusions: In the 8th stage ofthe full 9 stepped cycle closed chain of protons, the proton entry formed bicarbonate decreased in the red blood cell membrane surface, and ischemic standing nodule electron-proton leak and dehydrogenase enzyme activity was decreased significantly. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A study on structure and functions of organs involved in the formation of Mongolian Khuumii sound(Mongolian Journals Online, 2020-10-27); ; ; Palamdorj, Ganchimeg - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Efficacy of Marmot Brown Fat in Treatment of Acute Pancreatitis(Mongolian National University of Medical Sciences, 2016-06-25); ; ; Ariunaa ZunduinObjectives: The brown fat of marmots is called "human meat" among Mongolian people because they abstain from eating it. Our experimental study is the first academic-based study to investigate the effect of marmot brown fat (MBF) on acute pancreatitis (AP). Methods: This study used 82 healthy female Wistar rats (250-280 g). The study rats were divided into 4 groups: (1) relatively healthy (no medication and no AP, n = 10), (2) caerulein-induced AP rats without any treatments (n = 24), (3) AP rats fed by the MBF suspension (n = 24), and (4) AP rats injected with sandostatin (n = 24). The serum a-amylase level (SAAL) and histological examination were observed. Results: Significantly increased SAAL (group 1: 1347.10 ±10.76 units/L vs group 2: 1804.50 ±134.32 units/L) was confirmed in rats with caerulein-induced, mild AP. In both treatment groups 3 and 4, the SAAL was significantly decreased on the fifth day after treatment. Interestingly, advanced damage of pancreatic cells was observed in group 3. Additionally, the health condition of group 3 rats was poor, and spleen and lung tissue damage was detected by histological examination. Conclusion: Our study results suggest that the MBF suspension might be stimulating pancreatic juice secretion, therefore we conclude that the MBF suspension is not beneficial in the treatment of AP. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Tribulus Terrestris L Extract Effects on Slow Down Ageing Process(Mongolian National University of Medical Sciences, 2021-09-30); ; Rong, Bai MeiObjective: Tribulus Terrestris is a medicinal plant cultivated in temperate regions of the world. Inner Mongolia is one of the main producing areas of Tribulus Terrestris. We aimed in this study to examine the effect of Tribulus Terrestris extract on the aging process. Methods: A total of 50 mice were used for the experiment. They were divided randomly into 5 groups (10 animals in each group): normal control group and four aging groups. Results: Compared to the normal aging group, the parameters of the thymus gland and spleen of an aging group fed with a high and medium amount of Tribulus has visibly increased (p < 0.05). The content of blood catalase (CAT) and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) of blood serum of an aging group fed with a high and medium amount of Tribulus Terrestris has visibly increased (p < 0.05) compared to that in the aging group. Also, the content of malondialdehyde (MDA) in blood serum has visibly lowered. We further have measured the SOD, GSH-Px content in brain tissue of each group of mice. Conclusion: Compared with the normal control group, the SOD content was decreased significantly and MDA content was significantly increased in the aging group of mice. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Structure of The Choroid Plexus of Adult and Children Brain Ventricles(Elsevier BV, 2015-10-20); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Structural Changes in Vertebrae of Mice Based on Experimental Model of Rheumatoid Arthritis(Scientific Research Publishing, 2018-01-01); Studies have shown that autoimmunity causes pathogenesis of more than 100 diseases. Among these diseases, approximately 1-2% of the world’s population has rheumatoid arthritis disease, which is a chronic disease that affects 45 out of every 3000 people who have autoimmune diseases. The aim of this research is to address the possible treatment of rheumatoid arthritis disease by comparing and contrasting the effectiveness and influence that treatments have on treating the disease. This study will be conducted by inducing the following treatments: ibuprofen and Boigor-10 on model animal subjects (mice) to determine the outcomes of the treatment. We will assess the outcomes by investigate the structural changes on vertebrae and joints of these subjects and the clinical manifestation score of each treatment. We hypothesize that these treatments will improve the treatment of rheumatoid arthritis disease. Furthermore, we hope that this research contributes to further understanding autoimmune disease and promotes proper treatment of the disease. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative Study on Macroscopic Anatomy of Human Placenta in Term and Post Term Pregnancy(Mongolian National University of Medical Sciences, 2020-09-25); ; ; ; Objectives: We aimed to compare the macroscopic anatomy of human placenta in term and post-term pregnancy. Methods: This maternity hospital-based comparative study was carried out in Mongolia, in the year 2017-2018. For study purposes, placentae were collected from 1061 women between 17-44 years of age with live birth only. Term: 38 weeks to 40 weeks gestational period, and post-term: beyond 41 weeks gestational period. The macroscopic features of the placentae were measured as a standard protocol that is approved Department of Anatomy, Mongolian National University of Medical Sciences. Results: A total of rounded shapes was found in 72% of cases and oval in 26.3% cases, irregular shape in 1.7% cases of the three shape groups. The width and the weight of the placenta (t = 7.20, t = 13.27 respectively) were compared between groups term and post-term found to be significant (p < 0.001). Conclusions: We conclude that irrespective of term or post-term placentae, most of the placentae were round in shape. The averages of placental morphometric parameters of both of term or post-term placentae are in the normal limit. This study concludes that as the gestational period increases length, width, thickness, and weight of placenta increases in different. - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Preliminary Study Results of Native Mongolian Inonotus Obliquus Extracts in Alloxan-Induced Diabetic Rats(Mongolian National University of Medical Sciences, 2020-12-29); ; ; Objectives: We aimed to investigate the morphological changes and clinical chemistry panel of alloxan-induced diabetic rats for the treatment groups of ethanol or aqueous extracts of Mongolian natural Inonotus obliquus. Methods: Wistar albino rats (n = 80) were randomly assigned into four groups: 1. Healthy control group, 2. Untreated diabetic group, 3. Diabetic group treated with Inonotus obliquus (500 mg/kg per day) water extract, 4. Diabetic group with Inonotus obliquus (500 mg/kg per day) ethanol extract. Diabetes was induced by alloxan 150 mg/kg (single intraperitoneal injection) in the diabetic groups. Results: Both water and ethanol extract of Inonotus obliquus reduced the blood glucose level of diabetes at 48 h after treatment. Histologic and morphology examinations showed that water extracts of Inonotus obliquus alleviated the damage to pancreas tissues in alloxan diabetic rats. Conclusions: We postulate that simple ethanol and water extracts of natural Mongolian Inonotus obliquus have an antihyperglycemic effect that enhances islet cell function in alloxan-induced diabetic rats. The extracts of Mongolian natural Inonotus obliquus are easily producible at low cost and should be further explored as a treatment for diabetes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Аллоксаны чихрийн шижинтэй хулганы нойр булчирхайн эдийн бүтцийг судалсан дүн(2025-01-01); ; А.АвирмэдҮндэслэл: Аллоксан нь чихрийн шижингийн туршилтын амьтны загвар үүсгэхэд түгээмэл хэрэглэдэг химийн нэгдэл юм. 1943 онд ЗПаш ^ипп апй М ^ е 1сЫе нар аллоксан нь туршилтын амьтдын нойр булчирхайн р-эсэд өвөрмөц үхжил үүсгэдэг гэж мэдээлснээр аллоксаныг чихрийн шижин өвчинтэй холбон судлах болсон байна. Энэхүү судалгаагаар бид аллоксаноор үүсгэгдсэн чихрийн шижинтэй хулганы нойр булчирхайн эдийн бүтцийн өөрчлөлтийг үнэлсэн. Зорилго: Аллоксаны чихрийн шижинтэй хулганы нойр булчирхайн эдийн бүтцэд гарах өөрчлөлтийг судлах Арга, аргачлал: Чихрийн шижингийн эмгэг загвар үүсгэх протоколын дагуу С57В^/6 үүлдрийн 6-8 долоо хоногтой хулганад аллоксан моногидратыг хэвлийн хөндийд тарьж, чихрийн шижингийн эмгэг загварыг үүсгэн нойр булчирхайн эдийн бүтцийг үнэлсэн. Үр дүн: Аллоксаны чихрийн шижинтэй (АЧШ) бүлгийн хулганы нойр булчирхайн арлуудын төвд хүчтэй дегенератив өөрчлөлтийг үүсгэсэн. Арлын хэлбэр зөв биш, арлын төв хэсгээр харьцангуй сийрэгжиж, үхэжсэн (кариолизис) эсүүд ажиглагдсан. Нойр булчирхайн гадаад шүүрлийн хэсэгт ацинусын бүтэц хадгалагдсан, ациноцит эсүүдийн бөөм тод хөх өнгөөр будагдсан, зарим нэг ациноцит эсүүдийн сийвэн бөөмийн харьцаа алдагдаж, сийвэндээ хоосовч агуулсан, таславч хоорондын зай олширсон, цайвар өнгөтэй харагдаж байлаа. Туршилтын 7 дахь хоногт АЧШ бүлгийн хулганы нойр булчирхайн арлын хэсэгт р -эсүүдийн эерэг илэрхийлэл эрүүл хяналтын (ЭХ) бүлгийн хулганатай харьцуулахад багасаж, үхжилийн талбай үүссэн дүр зураг ажиглагдсан. 28 дахь хоногт р -эсүүдийн эерэг илэрхийлэл арлын төв хэсгээр тодорч харагдсан. Лангергансын арлын эерэг будагдсан эсүүдийн чанарын үзүүлэлтийг тоон утгад шилжүүлэн эзлэх хувийг тооцоход инсулин эерэг будагдсан эсийн талбайн эзлэх хувь ЭХ-ын бүлэгт 13.37±0.89, АЧШ бүлэгт 6.01±0.39 байв. Глюкагон эерэг будагдсан эсийн талбайн эзлэх хувь ЭХ-ын бүлэгт 15.27±1.11, АЧШ бүлэгт 5.01±0.58 байв. АЧШ бүлгийн хулганы нойр булчирхайн Лангергансын арлын талбайг ЭХ-ын бүлэгтэй харьцуулахад арлын талбай ихэссэн дүр зураг ажиглагдаж байлаа. Дүгнэлт: Үйл ажиллагааны сорилын үр дүнгээс харахад глюкоз хамааралт инсулины ялгарал туршилтын 28 хоногийн дараа идэвхтэй хэвээр байгааг тодорхойллоо. Аллоксаны нөлөөгөөр үүсч буй үхжил, апоптоз нь нойр булчирхайн Лангергансын арлын инсулин болон глюкагон эерэг будагдсан эсүүдийн эзлэх хувийг бууруулж байна.