Shuumarjav, Uurtuya
Loading...
Товч нэр
Shuumarjav, Uurtuya
Бүтэн нэр
Shuumarjav Uurtuya
Латин нэр
Shuumarjav Uurtuya
Албан тушаал
Судлаач
ORCID
Scopus Author ID
24 results
Now showing 1 - 10 of 24
- Some of the metrics are blocked by yourconsent settings
Item type:Publication, Osteoporosis in Mongolian Population: Prevalence and Risk Factors(Mongolian National University of Medical Sciences, 2017-11-25); ; ; ; Objectives: The purpose of this study was to evaluate the prevalence of osteoporosis and investigate some of its risk factors among Mongolian adults. Methods: The subjects comprised of 2001 adults (age ranged from 20 to 87) were recruited from 5 ecological zones of Mongolia. After applying exclusion criteria, 1990 subjects were selected. Speed of sound (SOS) ultrasonic bone mineral density was measured in the distal one third of radius of the non-dominant arm using the Sunlight Omnisense (Sunlight Medical, Rehovot, Israel). The data were used to calculate mean SOS and T-score by WHO osteoporosis criteria. Results: The average age was 49.1±13.5 (men: 48.6±14.6, women: 49.4±13.0). The prevalence of osteoporosis in men and women from 20-35 years of age was 4.7% vs 6.2%, from 36-45 years of age was 7.2% vs 8.0%, from ages 46-55 was 11.4% vs 25.5%, from ages 56-65 was 21.9% vs 58.3%, and from those over 65 years of age was 35.6% vs 75.5%. The prevalence of osteoporosis was lowest in Ulaanbaatar city. The independent predictors of osteoporosis in Mongolian adults were female sex, menopause, lower education level, physical inactivity and low BMI (BMI<18.5). Conclusion: Compared to neighboring and industrialized countries, the prevalence of osteoporosis in Mongolia is significantly higher. Female sex, lack of exercise, lower education level, menopause and being underweight were identified as risk factors in Mongolian adults. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ALDH18A1 Expression Profiling in Non-small Cell Lung Cancer through Bioinformatics and Experimental Approaches(Mongolian National University of Medical Sciences, 2026-05-21); Objective: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death worldwide. The molecular mechanisms of NSCLC are still not fully understood. This study used bioinformatics analysis of public databases to identify potential biomarkers and therapeutic targets. This study used integrated bioinformatics analyses to identify candidate oncogenes associated with in NSCLC. Tissue microarray-based immunohistochemistry was then performed to characterize the protein expression pattern of ALDH18A1 in NSCLC tissues and to preliminarily evaluate its potential as a biomarker. Methods: In this study, TCGA transcriptomic data were analyzed by weighted gene co-expression network analysis (WGCNA), differential expression analysis, least absolute shrinkage and selection operator (LASSO) regression, and random forest analysis to identify ALDH18A1 as a candidate gene in NSCLC. The protein expression of ALDH18A1 was then examined by immunohistochemistry (IHC) using tissue microarrays (TMAs) containing 80 lung squamous cell carcinoma samples, 52 lung adenocarcinoma samples, and their paired adjacent normal tissues. Results: In this study, WGCNA, differential expression analysis, LASSO regression, and random forest analysis identified ALDH18A1 as a key candidate gene in NSCLC. Immunohistochemical analysis showed that the expression level of ALDH18A1 protein was significantly higher in NSCLC tissues than in paired adjacent normal tissues (p < 0.05). Conclusions: ALDH18A1 is markedly upregulated in NSCLC and appears to contribute to tumorigenesis and disease progression, highlighting its promise as a potential diagnostic biomarker and a candidate target for therapeutic intervention. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A study on structure and functions of organs involved in the formation of Mongolian Khuumii sound(Mongolian Journals Online, 2020-10-27); ; ; Palamdorj, Ganchimeg - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Efficacy of Marmot Brown Fat in Treatment of Acute Pancreatitis(Mongolian National University of Medical Sciences, 2016-06-25); ; ; Ariunaa ZunduinObjectives: The brown fat of marmots is called "human meat" among Mongolian people because they abstain from eating it. Our experimental study is the first academic-based study to investigate the effect of marmot brown fat (MBF) on acute pancreatitis (AP). Methods: This study used 82 healthy female Wistar rats (250-280 g). The study rats were divided into 4 groups: (1) relatively healthy (no medication and no AP, n = 10), (2) caerulein-induced AP rats without any treatments (n = 24), (3) AP rats fed by the MBF suspension (n = 24), and (4) AP rats injected with sandostatin (n = 24). The serum a-amylase level (SAAL) and histological examination were observed. Results: Significantly increased SAAL (group 1: 1347.10 ±10.76 units/L vs group 2: 1804.50 ±134.32 units/L) was confirmed in rats with caerulein-induced, mild AP. In both treatment groups 3 and 4, the SAAL was significantly decreased on the fifth day after treatment. Interestingly, advanced damage of pancreatic cells was observed in group 3. Additionally, the health condition of group 3 rats was poor, and spleen and lung tissue damage was detected by histological examination. Conclusion: Our study results suggest that the MBF suspension might be stimulating pancreatic juice secretion, therefore we conclude that the MBF suspension is not beneficial in the treatment of AP. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Oral Pigmentation in Children: A Narrative Review and Practical Diagnostic Framework(Cureus, Inc., 2026-09-01); ; ; ; Oral pigmentation in childhood ranges from common constitutional variants to less frequent reactive, local, medication-related, vascular, genetic, endocrine, and neoplastic disorders.Overlapping clinical appearances can create diagnostic uncertainty, especially when adult-oriented approaches are applied to children.This narrative review presents a pediatric-focused framework for initial evaluation based on five domains: onset and evolution; focal, multifocal, or diffuse distribution; color and surface morphology; blanching or compressibility; and medication, dental, family, environmental, and systemic clues.Longstanding, symmetric, diffuse brown pigmentation without symptoms usually favors constitutional melanin pigmentation.Multifocal lentigines with gastrointestinal, endocrine, skeletal, or family-history findings should prompt targeted evaluation for an underlying syndrome.Blue-gray lesions adjacent to a restoration or trauma site suggest exogenous pigment, whereas red-blue compressible lesions raise concern for a vascular process and should not undergo blind biopsy.Oral melanoacanthoma is an important benign mimic because it may enlarge rapidly and appear clinically alarming.New or changing focal lesions, particularly those showing nodularity, ulceration, spontaneous bleeding, marked asymmetry, irregular borders, color variegation, or diagnostic uncertainty, warrant prompt specialist assessment and histopathologic evaluation when indicated.Pediatric evidence remains limited and consists largely of observational studies, case reports or series, and extrapolation from adult literature; accordingly, the proposed pathway is an evidenceinformed clinical aid rather than a validated prediction rule.A structured history-first approach can support appropriate reassurance, targeted referral, and timely biopsy while minimizing unnecessary intervention for convincingly benign pigmentation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Atherosclerotic Parameter Level Differences in Mongolian People Compared to Japanese People: A Brief Review of the LiteratureObjectives: In Mongolia, non-communicable disease caused morbidity and mortality related to lifestyle and metabolic diseases are increasing year after year. This review discusses the results of comparative studies related to lifestyle risk factors and the atherosclerotic parameters body mass index, glucose, insulin, and lipid level of Mongolian and Japanese people, as these are the known factors involved in metabolic and cardiovascular diseases. Methods: Academic literature was searched using electronic academic databases and handsearching reference lists for articles published in English and Mongolian on the topic. Results: The studies revealed that in comparison to Japanese subjects, a higher percentage of Mongolians smoked, and Mongolians had higher body mass index, heart rate, blood pressure, and insulin even though levels of serum total cholesterol and glucose were not different. Conclusion: The studies suggest that Mongolian people have higher risk of metabolic syndrome, which is a known main cause of CVDs, compared to Japanese people. On the other hand, climate, genetic and lifestyle differences might also increase non-communicable diseases in the Mongolian people. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dehydrocostus Lactone Down - regulates Lipopolysaccharide-induced SAA3 gene activation in the Microglia.(Mongolian National University of Medical Sciences, 2023-12-16); ; ; Running Title: DDL inhibits the LPS-induced SAA3 gene expression in microgliaObjective: Research on the mechanism of Dehydrocostus lactone (DDL) in microglial cells of the brain needs to be improved, despite its reported anti-inflammatory, anticancer, and anti-proliferation properties as a natural product of Eerdun Wurile The precise functions of the Serum amyloid A (SAA) genes are not yet defined. However, these genes are suggested to possess antibacterial properties and can attract monocytes and neutrophils. On the other hand, SAA genes can also induce inflammatory cytokines and metalloproteinases in smooth muscle cells and macrophages, thus promoting inflammation. This study aimed to investigate the impact of DDL on SAA3 gene expression in microglial cells stimulated by LPS.Methods: The anti-inflammatory effects of DDL were studied using LPS-stimulated murine BV2 microglia. BV2 was cultured in DMEM, and then 4µM DDL was added. Then BV2 was treated with one ng/ml LPS for 24 hours to stimulate. Results: LPS treatment increased the expression of SAA3 mRNA in BV2 microglial cells, while DDL pre-treatment inhibited LPS-induced SAA3 mRNA expression.Conclusion: Microglia cells treated with LPS display a significant reduction in the expression of SAA3 gene transcripts upon treatment with DDL. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Ясны хугаралд нөлөөлөх зарим эрсдэлт хүчин зүйлийг судалсан дүн(2025-01-01); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Бодисын солилцооны хам шинж ба гиперферритинеми хоорондын хамаарлыг судалсан үр дүн(2025-01-01); Э.СарантуяаҮндэслэл: Гиперферритинеми гэдэг нь ийлдсэн дэх ферритиний Ферритин агууламж хэвийн утгаас нэмэгдэхийг хэлдэг бөгөөд дэлхийн хэмжээнд Таргалалт нийт хүн амын 5-25%-д тохиолддог. Элэгний төмрийн хэт ачааллын хам Гипергликеми шинж болон бодисын солилцооны хам шинж (БСХШ) нь хоорондоо хамааралтай бөгөөд энэ нь дэлхий дахинд өвчлөл болон нас баралтын чухал шалтгаануудын нэгд тооцогддог тул судлаачид дээрх хамаарлыг судлах шаардлагатай байна. Олон улсад болон Монгол улсад бодисын солилцооны хам шинж болон зарим эмгэгүүдийн үед төмрийн солилцоо алдагдаж, төмрийн ачаалалд хүргэж байгаа эсэхийг үнэлсэн нотолгоо хомс байна. Иймд бид гиперферритинеми ба БСХШ болон бусад хүчин зүйлсийн хамаарлыг судлахаар зорилоо. Арга, аргачлал: Судалгааг аналитик судалгааны агшингийн загвар ашиглан гүйцэтгэв. Судалгаанд хамруулах шалгуурыг хангасан 159 эрэгтэй хүний мэдээлэлд дүн шинжилгээ хийв. Судалгаанд оролцогчдоос асуумж судалгаа авч, бие махбодын хэмжилтүүдийг хийв. Судалгаанд оролцогчдын венийн цуснаас шинжилгээ авч өлөн үеийн глюкоз, триглицерид, нийт холестрин, ИНЛП, төмрийн түвшинг биохимийн бүрэн автомат анализатораар тодорхойлов. Судалгаанд оролцогчдын ферритиний түвшинг үнэлэхдээ Е И 8А аргыг ашиглан тодорхойлов ф К О 1п§1ттеп1§ ОтЪН, Оегтапу). Бид ийлдсийн ферритиний түвшин 400пд/т1-с дээш тохиолдолд гиперферртинеми гэж үзсэн. БСХШ-г тодорхойлохдоо “Н агтотгей 1” шалгуурыг ашигласан. Судалгааны гиперферритинеми болон хэвийн хоёр бүлэгт чанарын хувьсагч хоорондын ялгааг тооцохдоо Хи-квадрат тест болон Рт§Ъег Ехас1 тест, тоон хувьсагчийн дунджийн ялгааг тооцохдоо Мапп ^ЫШпеу ^ тест ашиглав. Судалгаанд оролцогчдын глюкозын түвшин, өөх тосны үзүүлэлтүүд ба ферритиний түвшин хооронд хамаарлыг үнэлэхдээ спеарманы корреляцийн шинжилгээг ашиглав. Үр дүн: Судалгаанд оролцогчдын 59 (37.1%) нь бодисын солилцооны хам шинжтэй, 33 (20.8%)-д гиперферритинеми тодорхойлогдов. Гиперферритинеми болох эрсдэлийг бодисын солилцооны хам шинжтэй байх нь 3.4 дахин, гипергликемитэй байх нь 3.7 дахин, хэвлийн таргалалттай байх нь 2.2 дахин нэмэгдүүлж байв. Дүгнэлт: Судалгаанд оролцсон эрэгтэй хүмүүсийн ферритиний түвшин өндөр байх нь бодисын солилцооны хам шинж болон түүний зарим үзүүлэлтүүдтэй (хэвлийн тойрог, гипергликеми) ач холбогдол бүхий хамааралтай үнэлэгдэв. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Орчны тамхины утааны шалтгаантай хүүхдийн амны салстын нөсөөжилт: системчилсэн тойм ба мета-анализ(2026-05-22); ; Үндэслэл: Хүүхдийн дам тамхидалт (ДТ) нь нийгмийн эрүүл мэндийн ноцтой асуудлын нэг бөгөөд эцэг эхийн тамхины хэрэглээнээс шалтгаалан гэрийн орчны тамхины өртөлтөөс зайлсхийх боломж хязгаарлагдмал байдаг. Сүүлийн жилүүдэд амны салстын нөсөөжилт (АСН) нь хүүхдийн удаан хугацааны идэвхгүй тамхидалтыг илтгэгч эмнэлзүйн шинж тэмдэг болох талаар судлаачид анхаарч байгаа ч, үр дүнг нэгтгэсэн судалгаа хараахан хийгдээгүй байна. Зорилго: Хүүхдийн дам тамхидалт болон амны салстын нөсөөжилтийн хамаарлыг нэгтгэн дүгнэх. Арга, аргачлал: PRISMA удирдамжийн дагуу PubMed, Scopus, Web of Science, Cochrane Library гэх мэдээллийн санаас системтэй хайлт хийж, хүүхдийн (≤18 нас) ДТ болон АСН-ийн хамаарлыг үнэлсэн, ажиглалт судалгаануудыг түүвэрлэж, тэдгээрийн аргазүйн чанарыг Mixed Methods Appraisal Tool (MMAT)-ийн тусламжтайгаар үнэлэв. Санамсаргүй нөлөөт загвар бүхий мета-анализ хийж, нэгтгэсэн OR-ыг 95%-ийн итгэлцлийн интервал (CI)-аар тооцон, судалгаа хоорондын ялгаатай байдлыг I²-аар, нотолгооны итгэлцлийг GRADE-аар тус тус үнэлэв. Үр дүн: Нийт 1,582 оролцогч бүхий 7 судалгаа шалгуурт нийцлээ. Мета-анализийн шинжилгээгээр ДТ нь АСН-ийн эрсдэлийг нэмэгдүүлдэг нь тодорхойлогдож (нэгтгэсэн OR 2.58, 95% CI:1.35–4.95, p=0.004), ДТ-ын өртөлттэй бүлгийг өртөлтгүй бүлэгтэй харьцуулахад үнэмлэхүйн эрсдлийн өсөлт 17% (95% CI 6.3–23.9%)-тай байлаа. Үнэлгээний аргачлалаар үүсгэсэн дэд бүлгийн анализаар Gingival Pigmentation Index (GPI) хэрэглэсэн судалгаануудад тогтвортой нөлөө илэрч байсан (OR 2.12, 95% CI 1.58–2.84) бол Dummett Oral Pigmentation Index (DOPI)-ээр үнэлсэн судалгаанд итгэлцлийн интервал өргөн хүрээтэй байлаа (OR 3.26, 95% CI 0.68–15.54). MMAT үнэлгээгээр хамрагдсан судалгаанд оролцогчийн сонголт хангалттай буюу 100%тай, үр дүнгийн хэмжилтийн зохистой байдал 76.9%, төөрөгдүүлэгч хүчин зүйлсийг хянасан байдал 46.2%-тай байв. Ажиглалт судалгааны загвар, дунд зэргийн хетероген шинж, физиологийн нөсөөжилтөөр төөрөгдүүлэгч эрсдэл зэргээс шалтгаалан, GRADE-ээр тодорхойлогдсон нотолгооны итгэлцэл бага гэж үнэлэгдсэн болно. Дүгнэлт: Орчны тамхины утаанд өртсөн хүүхдүүдэд үүсэх амны салстын нөсөөжилтийн магадлал өртөөгүй бүлгийнхээс мэдэгдэхүйц өндөр байв. Эдгээр үр дүн нь хүүхдийн амны хөндийн үзлэгт салстын нөсөөжилтийн илрүүлгийг оруулах нь дам тамхидалтын инвазив бус маркер, мөн өрхийн орчин дахь тамхинаас татгалзах талаар эцэг эхэд баримт болгон зөвлөгөө өгөхөд ашиглах боломжтойг харуулж байна.